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Agreement in cerebrovascular reactivity assessed with diffuse correlation spectroscopy across experimental paradigms improves with short separation regression
SIGNIFICANCE: Cerebrovascular reactivity (CVR), i.e., the ability of cerebral vasculature to dilate or constrict in response to vasoactive stimuli, is a biomarker of vascular health. Exogenous administration of inhaled carbon dioxide, i.e., hypercapnia (HC), remains the “gold-standard” intervention...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079775/ https://www.ncbi.nlm.nih.gov/pubmed/37034012 http://dx.doi.org/10.1117/1.NPh.10.2.025002 |
Sumario: | SIGNIFICANCE: Cerebrovascular reactivity (CVR), i.e., the ability of cerebral vasculature to dilate or constrict in response to vasoactive stimuli, is a biomarker of vascular health. Exogenous administration of inhaled carbon dioxide, i.e., hypercapnia (HC), remains the “gold-standard” intervention to assess CVR. More tolerable paradigms that enable CVR quantification when HC is difficult/contraindicated have been proposed. However, because these paradigms feature mechanistic differences in action, an assessment of agreement of these more tolerable paradigms to HC is needed. AIM: We aim to determine the agreement of CVR assessed during HC, breath-hold (BH), and resting state (RS) paradigms. APPROACH: Healthy adults were subject to HC, BH, and RS paradigms. End tidal carbon dioxide (EtCO(2)) and cerebral blood flow (CBF, assessed with diffuse correlation spectroscopy) were monitored continuously. CVR (%/mmHg) was quantified via linear regression of CBF versus EtCO(2) or via a general linear model (GLM) that was used to minimize the influence of systemic and extracerebral signal contributions. RESULTS: Strong agreement ([Formula: see text]; [Formula: see text]) among CVR paradigms was demonstrated when utilizing a GLM to regress out systemic/extracerebral signal contributions. Linear regression alone showed poor agreement across paradigms ([Formula: see text]; [Formula: see text]). CONCLUSIONS: More tolerable experimental paradigms coupled with regression of systemic/extracerebral signal contributions may offer a viable alternative to HC for assessing CVR. |
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