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The interplay between herbal medicines and gut microbiota in metabolic diseases

Globally, metabolic diseases are becoming a major public health problem. Herbal medicines are medicinal materials or preparations derived from plants and are widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that...

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Autores principales: Wang, Lijie, Gou, Xiaoling, Ding, Yin, Liu, Jingye, Wang, Yue, Wang, Yaqian, Zhang, Jing, Du, Leilei, Peng, Wei, Fan, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079915/
https://www.ncbi.nlm.nih.gov/pubmed/37033634
http://dx.doi.org/10.3389/fphar.2023.1105405
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author Wang, Lijie
Gou, Xiaoling
Ding, Yin
Liu, Jingye
Wang, Yue
Wang, Yaqian
Zhang, Jing
Du, Leilei
Peng, Wei
Fan, Gang
author_facet Wang, Lijie
Gou, Xiaoling
Ding, Yin
Liu, Jingye
Wang, Yue
Wang, Yaqian
Zhang, Jing
Du, Leilei
Peng, Wei
Fan, Gang
author_sort Wang, Lijie
collection PubMed
description Globally, metabolic diseases are becoming a major public health problem. Herbal medicines are medicinal materials or preparations derived from plants and are widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that gut microbiota plays an important role in the herbal treatment of metabolic diseases. However, the mechanisms involved are still not fully understood. This review provides a timely and comprehensive summary of the interactions between herbal medicines and gut microbiota in metabolic diseases. Mechanisms by which herbal medicines treat metabolic diseases include their effects on the gut microbial composition, the intestinal barrier, inflammation, and microbial metabolites (e.g., short-chain fatty acids and bile acids). Herbal medicines can increase the abundance of beneficial bacteria (e.g., Akkermansia and Blautia), reduce the abundance of harmful bacteria (e.g., Escherichia–Shigella), protect the intestinal barrier, and alleviate inflammation. In turn, gut microbes can metabolize herbal compounds and thereby increase their bioavailability and bioactivity, in addition to reducing their toxicity. These findings suggest that the therapeutic effects of herbal medicines on metabolic diseases are closely related to their interactions with the gut microbiota. In addition, some methods, and techniques for studying the bidirectional interaction between herbal medicines and gut microbiota are proposed and discussed. The information presented in this review will help with a better understanding of the therapeutic mechanisms of herbal medicines and the key role of gut microbiota.
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spelling pubmed-100799152023-04-08 The interplay between herbal medicines and gut microbiota in metabolic diseases Wang, Lijie Gou, Xiaoling Ding, Yin Liu, Jingye Wang, Yue Wang, Yaqian Zhang, Jing Du, Leilei Peng, Wei Fan, Gang Front Pharmacol Pharmacology Globally, metabolic diseases are becoming a major public health problem. Herbal medicines are medicinal materials or preparations derived from plants and are widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that gut microbiota plays an important role in the herbal treatment of metabolic diseases. However, the mechanisms involved are still not fully understood. This review provides a timely and comprehensive summary of the interactions between herbal medicines and gut microbiota in metabolic diseases. Mechanisms by which herbal medicines treat metabolic diseases include their effects on the gut microbial composition, the intestinal barrier, inflammation, and microbial metabolites (e.g., short-chain fatty acids and bile acids). Herbal medicines can increase the abundance of beneficial bacteria (e.g., Akkermansia and Blautia), reduce the abundance of harmful bacteria (e.g., Escherichia–Shigella), protect the intestinal barrier, and alleviate inflammation. In turn, gut microbes can metabolize herbal compounds and thereby increase their bioavailability and bioactivity, in addition to reducing their toxicity. These findings suggest that the therapeutic effects of herbal medicines on metabolic diseases are closely related to their interactions with the gut microbiota. In addition, some methods, and techniques for studying the bidirectional interaction between herbal medicines and gut microbiota are proposed and discussed. The information presented in this review will help with a better understanding of the therapeutic mechanisms of herbal medicines and the key role of gut microbiota. Frontiers Media S.A. 2023-03-24 /pmc/articles/PMC10079915/ /pubmed/37033634 http://dx.doi.org/10.3389/fphar.2023.1105405 Text en Copyright © 2023 Wang, Gou, Ding, Liu, Wang, Wang, Zhang, Du, Peng and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wang, Lijie
Gou, Xiaoling
Ding, Yin
Liu, Jingye
Wang, Yue
Wang, Yaqian
Zhang, Jing
Du, Leilei
Peng, Wei
Fan, Gang
The interplay between herbal medicines and gut microbiota in metabolic diseases
title The interplay between herbal medicines and gut microbiota in metabolic diseases
title_full The interplay between herbal medicines and gut microbiota in metabolic diseases
title_fullStr The interplay between herbal medicines and gut microbiota in metabolic diseases
title_full_unstemmed The interplay between herbal medicines and gut microbiota in metabolic diseases
title_short The interplay between herbal medicines and gut microbiota in metabolic diseases
title_sort interplay between herbal medicines and gut microbiota in metabolic diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079915/
https://www.ncbi.nlm.nih.gov/pubmed/37033634
http://dx.doi.org/10.3389/fphar.2023.1105405
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