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Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible patterns. We proposed an approach for the compensatory stimulati...

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Autores principales: Mikhailova, Yulia, Pozdeeva, Anna, Suleimanova, Alina, Leukhin, Alexey, Toschev, Alexander, Lukmanov, Timur, Fatyhova, Elsa, Magid, Evgeni, Lavrov, Igor, Talanov, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079922/
https://www.ncbi.nlm.nih.gov/pubmed/37034155
http://dx.doi.org/10.3389/fnins.2023.1113867
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author Mikhailova, Yulia
Pozdeeva, Anna
Suleimanova, Alina
Leukhin, Alexey
Toschev, Alexander
Lukmanov, Timur
Fatyhova, Elsa
Magid, Evgeni
Lavrov, Igor
Talanov, Max
author_facet Mikhailova, Yulia
Pozdeeva, Anna
Suleimanova, Alina
Leukhin, Alexey
Toschev, Alexander
Lukmanov, Timur
Fatyhova, Elsa
Magid, Evgeni
Lavrov, Igor
Talanov, Max
author_sort Mikhailova, Yulia
collection PubMed
description The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible patterns. We proposed an approach for the compensatory stimulation device as implementation of previously presented architecture of the neurointerface, where (1) the neuroport is implemented as a DAC and stimulator, (2) neuroterminal is used for neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with five volunteers, we measured the efficacy of motor neuron inhibition via the antagonist muscle or nerve stimulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both the agonist and the antagonist muscles and nerves, we experimented with delays between muscle stimulation in the range of 0–20 ms. We registered the subjective discomfort rate. We did not identify any significant difference between the antagonist muscle and nerve stimulation in both voluntary activity and electrical stimulation of cases showing agonist activity. We determined the most effective delay between the stimulation of the agonist and the antagonist muscles and nerves as 10–20 ms.
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spelling pubmed-100799222023-04-08 Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles Mikhailova, Yulia Pozdeeva, Anna Suleimanova, Alina Leukhin, Alexey Toschev, Alexander Lukmanov, Timur Fatyhova, Elsa Magid, Evgeni Lavrov, Igor Talanov, Max Front Neurosci Neuroscience The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible patterns. We proposed an approach for the compensatory stimulation device as implementation of previously presented architecture of the neurointerface, where (1) the neuroport is implemented as a DAC and stimulator, (2) neuroterminal is used for neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with five volunteers, we measured the efficacy of motor neuron inhibition via the antagonist muscle or nerve stimulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both the agonist and the antagonist muscles and nerves, we experimented with delays between muscle stimulation in the range of 0–20 ms. We registered the subjective discomfort rate. We did not identify any significant difference between the antagonist muscle and nerve stimulation in both voluntary activity and electrical stimulation of cases showing agonist activity. We determined the most effective delay between the stimulation of the agonist and the antagonist muscles and nerves as 10–20 ms. Frontiers Media S.A. 2023-03-24 /pmc/articles/PMC10079922/ /pubmed/37034155 http://dx.doi.org/10.3389/fnins.2023.1113867 Text en Copyright © 2023 Mikhailova, Pozdeeva, Suleimanova, Leukhin, Toschev, Lukmanov, Fatyhova, Magid, Lavrov and Talanov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mikhailova, Yulia
Pozdeeva, Anna
Suleimanova, Alina
Leukhin, Alexey
Toschev, Alexander
Lukmanov, Timur
Fatyhova, Elsa
Magid, Evgeni
Lavrov, Igor
Talanov, Max
Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title_full Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title_fullStr Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title_full_unstemmed Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title_short Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
title_sort neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079922/
https://www.ncbi.nlm.nih.gov/pubmed/37034155
http://dx.doi.org/10.3389/fnins.2023.1113867
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