Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in mitochondrial damage and oxidative stress, which can cause further progression of CKD. Methods: This study assessed the therapeutic effect...

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Detalles Bibliográficos
Autores principales: Gui, Ting, Chen, Qingfa, Li, Jiangsong, Lu, Ke, Li, Chen, Xu, Bin, Chen, Yang, Men, Jingwen, Kullak-Ublick, Gerd A., Wang, Weihua, Gai, Zhibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079923/
https://www.ncbi.nlm.nih.gov/pubmed/37033627
http://dx.doi.org/10.3389/fphar.2023.1092475

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