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Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease
Gut microecosystem has been shown to play an important role in human health. In recent years, the concept of the gut-kidney axis has been proposed to explain the potential association between gut microbiota and chronic kidney disease (CKD). Here, a cohort of fecal samples collected from patients wit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079997/ https://www.ncbi.nlm.nih.gov/pubmed/37033494 http://dx.doi.org/10.3389/fcimb.2023.1105366 |
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author | Chen, Hao Wang, Jingyan Ouyang, Qin Peng, Xinyue Yu, Zheng Wang, Jianwen Huang, Jing |
author_facet | Chen, Hao Wang, Jingyan Ouyang, Qin Peng, Xinyue Yu, Zheng Wang, Jianwen Huang, Jing |
author_sort | Chen, Hao |
collection | PubMed |
description | Gut microecosystem has been shown to play an important role in human health. In recent years, the concept of the gut-kidney axis has been proposed to explain the potential association between gut microbiota and chronic kidney disease (CKD). Here, a cohort of fecal samples collected from patients with CKD (n = 13) were involved. The composition of gut microbial communities and clinical features in CKD and end-stage renal disease (ESRD) were characterized. Our study focused on the changes in gut microbiome and the correlation with clinical features in patients with CKD and ESRD by analyzing high-throughput sequencing results of collected feces. We elucidated the alterations of gut microbiota in CKD patients at different stages of disease and initially identified the gut microbiota associated with CKD progression. We also combined correlation analysis to identify clinical features closely related to the gut microbiome. Our results offered the possibility of using non-invasive gut microbiome in the early diagnosis of course from CKD to ESRD and provide new insights into the association between clinical features and gut microbiota in CKD. |
format | Online Article Text |
id | pubmed-10079997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100799972023-04-08 Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease Chen, Hao Wang, Jingyan Ouyang, Qin Peng, Xinyue Yu, Zheng Wang, Jianwen Huang, Jing Front Cell Infect Microbiol Cellular and Infection Microbiology Gut microecosystem has been shown to play an important role in human health. In recent years, the concept of the gut-kidney axis has been proposed to explain the potential association between gut microbiota and chronic kidney disease (CKD). Here, a cohort of fecal samples collected from patients with CKD (n = 13) were involved. The composition of gut microbial communities and clinical features in CKD and end-stage renal disease (ESRD) were characterized. Our study focused on the changes in gut microbiome and the correlation with clinical features in patients with CKD and ESRD by analyzing high-throughput sequencing results of collected feces. We elucidated the alterations of gut microbiota in CKD patients at different stages of disease and initially identified the gut microbiota associated with CKD progression. We also combined correlation analysis to identify clinical features closely related to the gut microbiome. Our results offered the possibility of using non-invasive gut microbiome in the early diagnosis of course from CKD to ESRD and provide new insights into the association between clinical features and gut microbiota in CKD. Frontiers Media S.A. 2023-03-24 /pmc/articles/PMC10079997/ /pubmed/37033494 http://dx.doi.org/10.3389/fcimb.2023.1105366 Text en Copyright © 2023 Chen, Wang, Ouyang, Peng, Yu, Wang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Chen, Hao Wang, Jingyan Ouyang, Qin Peng, Xinyue Yu, Zheng Wang, Jianwen Huang, Jing Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title | Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title_full | Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title_fullStr | Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title_full_unstemmed | Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title_short | Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
title_sort | alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079997/ https://www.ncbi.nlm.nih.gov/pubmed/37033494 http://dx.doi.org/10.3389/fcimb.2023.1105366 |
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