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An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone

This 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in pa...

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Autores principales: Čermák, Jan, Pietrucha, Slavomír, Nawka, Alexander, Lipone, Paola, Ruggieri, Alessandro, Bonelli, Annalisa, Comandini, Alessandro, Cattaneo, Agnese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080076/
https://www.ncbi.nlm.nih.gov/pubmed/37032913
http://dx.doi.org/10.3389/fpsyt.2023.1127511
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author Čermák, Jan
Pietrucha, Slavomír
Nawka, Alexander
Lipone, Paola
Ruggieri, Alessandro
Bonelli, Annalisa
Comandini, Alessandro
Cattaneo, Agnese
author_facet Čermák, Jan
Pietrucha, Slavomír
Nawka, Alexander
Lipone, Paola
Ruggieri, Alessandro
Bonelli, Annalisa
Comandini, Alessandro
Cattaneo, Agnese
author_sort Čermák, Jan
collection PubMed
description This 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in patients with major depressive disorder (MDD) treated with trazodone once a day (OAD). Overall, 11 out of 30 planned patients were enrolled. Passive parameters measured by the wearable device included number of steps, distance walked, calories burned, and sleep quality. A relationship between the sleep score (derived from passively measured data) and MADRS score was observed, as was a relationship between data collected actively (assessing depression, sleep, anxiety, and warning signs) and MADRS score. Despite the limited sample size, the efficacy and safety results were consistent with those previously reported for trazodone. The small population in this study limits the conclusions that can be drawn about the correlation between the digital phenotyping approach and traditional clinical evaluation; however, the positive trends observed suggest the need to increase synergies among clinicians, patients, and researchers to overcome the cultural barriers toward implementation of digital tools in the clinical setting. This study is a step toward the use of digital data in monitoring symptoms of depression, and the preliminary data obtained encourage further investigations of a larger population of patients monitored over a longer period of time.
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spelling pubmed-100800762023-04-08 An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone Čermák, Jan Pietrucha, Slavomír Nawka, Alexander Lipone, Paola Ruggieri, Alessandro Bonelli, Annalisa Comandini, Alessandro Cattaneo, Agnese Front Psychiatry Psychiatry This 8-week study was designed to explore any correlation between a passive data collection approach using a wearable device (i.e., digital phenotyping), active data collection (patient’s questionnaires), and a traditional clinical evaluation [Montgomery-Åsberg Depression Rating Scale (MADRS)] in patients with major depressive disorder (MDD) treated with trazodone once a day (OAD). Overall, 11 out of 30 planned patients were enrolled. Passive parameters measured by the wearable device included number of steps, distance walked, calories burned, and sleep quality. A relationship between the sleep score (derived from passively measured data) and MADRS score was observed, as was a relationship between data collected actively (assessing depression, sleep, anxiety, and warning signs) and MADRS score. Despite the limited sample size, the efficacy and safety results were consistent with those previously reported for trazodone. The small population in this study limits the conclusions that can be drawn about the correlation between the digital phenotyping approach and traditional clinical evaluation; however, the positive trends observed suggest the need to increase synergies among clinicians, patients, and researchers to overcome the cultural barriers toward implementation of digital tools in the clinical setting. This study is a step toward the use of digital data in monitoring symptoms of depression, and the preliminary data obtained encourage further investigations of a larger population of patients monitored over a longer period of time. Frontiers Media S.A. 2023-03-24 /pmc/articles/PMC10080076/ /pubmed/37032913 http://dx.doi.org/10.3389/fpsyt.2023.1127511 Text en Copyright © 2023 Čermák, Pietrucha, Nawka, Lipone, Ruggieri, Bonelli, Comandini and Cattaneo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Čermák, Jan
Pietrucha, Slavomír
Nawka, Alexander
Lipone, Paola
Ruggieri, Alessandro
Bonelli, Annalisa
Comandini, Alessandro
Cattaneo, Agnese
An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title_full An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title_fullStr An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title_full_unstemmed An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title_short An Observational Pilot Study using a Digital Phenotyping Approach in Patients with Major Depressive Disorder Treated with Trazodone
title_sort observational pilot study using a digital phenotyping approach in patients with major depressive disorder treated with trazodone
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080076/
https://www.ncbi.nlm.nih.gov/pubmed/37032913
http://dx.doi.org/10.3389/fpsyt.2023.1127511
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