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Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model

Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is toxic to neurons and currently no effective treatment exists. Function of both normal and mutant ataxin-3 is pleiotropic by th...

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Detalles Bibliográficos
Autores principales: Piasecki, Piotr, Wiatr, Kalina, Ruszkowski, Milosz, Marczak, Łukasz, Trottier, Yvon, Figiel, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080164/
https://www.ncbi.nlm.nih.gov/pubmed/37033372
http://dx.doi.org/10.3389/fnmol.2023.1122308

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