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Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer

INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc level...

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Autores principales: Namikawa, Tsutomu, Utsunomiya, Masato, Yokota, Keiichiro, Munekage, Masaya, Uemura, Sunao, Maeda, Hiromichi, Kitagawa, Hiroyuki, Kobayashi, Michiya, Hanazaki, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080202/
https://www.ncbi.nlm.nih.gov/pubmed/37035095
http://dx.doi.org/10.1159/000529707
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author Namikawa, Tsutomu
Utsunomiya, Masato
Yokota, Keiichiro
Munekage, Masaya
Uemura, Sunao
Maeda, Hiromichi
Kitagawa, Hiroyuki
Kobayashi, Michiya
Hanazaki, Kazuhiro
author_facet Namikawa, Tsutomu
Utsunomiya, Masato
Yokota, Keiichiro
Munekage, Masaya
Uemura, Sunao
Maeda, Hiromichi
Kitagawa, Hiroyuki
Kobayashi, Michiya
Hanazaki, Kazuhiro
author_sort Namikawa, Tsutomu
collection PubMed
description INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. METHODS: The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level <80 μg/dL. RESULTS: The median zinc level of the 83 patients was 73 μg/dL (range, 20–152 μg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, p < 0.001), and the median serum zinc level was significantly lower in the albumin <4.1 g/dL group than in the albumin ≥4.1 g/dL group (69 μg/dL vs. 82 μg/dL, p < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1,500 vs. 1810 years, p = 0.041). The median serum zinc level was significantly lower in the age ≥74 group than in the age <74 (71 μg/dL vs. 76 μg/dL, p = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, p = 0.009). CONCLUSION: Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin.
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spelling pubmed-100802022023-04-08 Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer Namikawa, Tsutomu Utsunomiya, Masato Yokota, Keiichiro Munekage, Masaya Uemura, Sunao Maeda, Hiromichi Kitagawa, Hiroyuki Kobayashi, Michiya Hanazaki, Kazuhiro Gastrointest Tumors Research Article INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. METHODS: The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level <80 μg/dL. RESULTS: The median zinc level of the 83 patients was 73 μg/dL (range, 20–152 μg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, p < 0.001), and the median serum zinc level was significantly lower in the albumin <4.1 g/dL group than in the albumin ≥4.1 g/dL group (69 μg/dL vs. 82 μg/dL, p < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1,500 vs. 1810 years, p = 0.041). The median serum zinc level was significantly lower in the age ≥74 group than in the age <74 (71 μg/dL vs. 76 μg/dL, p = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, p = 0.009). CONCLUSION: Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin. S. Karger AG 2023-02-27 /pmc/articles/PMC10080202/ /pubmed/37035095 http://dx.doi.org/10.1159/000529707 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Namikawa, Tsutomu
Utsunomiya, Masato
Yokota, Keiichiro
Munekage, Masaya
Uemura, Sunao
Maeda, Hiromichi
Kitagawa, Hiroyuki
Kobayashi, Michiya
Hanazaki, Kazuhiro
Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title_full Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title_fullStr Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title_full_unstemmed Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title_short Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
title_sort association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080202/
https://www.ncbi.nlm.nih.gov/pubmed/37035095
http://dx.doi.org/10.1159/000529707
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