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Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer
INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc level...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080202/ https://www.ncbi.nlm.nih.gov/pubmed/37035095 http://dx.doi.org/10.1159/000529707 |
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author | Namikawa, Tsutomu Utsunomiya, Masato Yokota, Keiichiro Munekage, Masaya Uemura, Sunao Maeda, Hiromichi Kitagawa, Hiroyuki Kobayashi, Michiya Hanazaki, Kazuhiro |
author_facet | Namikawa, Tsutomu Utsunomiya, Masato Yokota, Keiichiro Munekage, Masaya Uemura, Sunao Maeda, Hiromichi Kitagawa, Hiroyuki Kobayashi, Michiya Hanazaki, Kazuhiro |
author_sort | Namikawa, Tsutomu |
collection | PubMed |
description | INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. METHODS: The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level <80 μg/dL. RESULTS: The median zinc level of the 83 patients was 73 μg/dL (range, 20–152 μg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, p < 0.001), and the median serum zinc level was significantly lower in the albumin <4.1 g/dL group than in the albumin ≥4.1 g/dL group (69 μg/dL vs. 82 μg/dL, p < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1,500 vs. 1810 years, p = 0.041). The median serum zinc level was significantly lower in the age ≥74 group than in the age <74 (71 μg/dL vs. 76 μg/dL, p = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, p = 0.009). CONCLUSION: Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin. |
format | Online Article Text |
id | pubmed-10080202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-100802022023-04-08 Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer Namikawa, Tsutomu Utsunomiya, Masato Yokota, Keiichiro Munekage, Masaya Uemura, Sunao Maeda, Hiromichi Kitagawa, Hiroyuki Kobayashi, Michiya Hanazaki, Kazuhiro Gastrointest Tumors Research Article INTRODUCTION: Although it was reported that serum zinc levels were lower in patients with various malignancies, serum zinc levels of patients with gastric cancer were not well documented. OBJECTIVES: This study aimed to evaluate the association between clinicopathologic features and serum zinc levels in preoperative patients with gastric cancer. METHODS: The study enrolled 83 patients scheduled for gastric cancer surgery at the Kochi Medical School. Clinical data were obtained to investigate associations between clinicopathological features, including nutritional indicators and serum zinc levels. Serum zinc deficiency was defined as serum zinc level <80 μg/dL. RESULTS: The median zinc level of the 83 patients was 73 μg/dL (range, 20–152 μg/dL), and serum zinc deficiency was present in 66.3% of patients. Albumin was significantly lower in the zinc low level group than in the normal group (3.9 g/dL vs. 4.4 g/dL, p < 0.001), and the median serum zinc level was significantly lower in the albumin <4.1 g/dL group than in the albumin ≥4.1 g/dL group (69 μg/dL vs. 82 μg/dL, p < 0.001). Lymphocyte count was significantly lower in the zinc low level group than in the normal group (1,500 vs. 1810 years, p = 0.041). The median serum zinc level was significantly lower in the age ≥74 group than in the age <74 (71 μg/dL vs. 76 μg/dL, p = 0.002). Serum zinc levels showed a significant positive correlation with serum albumin (r = 0.637, p = 0.009). CONCLUSION: Serum zinc deficiency was found in 66.3% of preoperative patients with gastric cancer, which was highly correlated with serum albumin. S. Karger AG 2023-02-27 /pmc/articles/PMC10080202/ /pubmed/37035095 http://dx.doi.org/10.1159/000529707 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Research Article Namikawa, Tsutomu Utsunomiya, Masato Yokota, Keiichiro Munekage, Masaya Uemura, Sunao Maeda, Hiromichi Kitagawa, Hiroyuki Kobayashi, Michiya Hanazaki, Kazuhiro Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title | Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title_full | Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title_fullStr | Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title_full_unstemmed | Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title_short | Association between Serum Zinc Levels and Clinicopathological Characteristics in Patients with Gastric Cancer |
title_sort | association between serum zinc levels and clinicopathological characteristics in patients with gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080202/ https://www.ncbi.nlm.nih.gov/pubmed/37035095 http://dx.doi.org/10.1159/000529707 |
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