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B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report
BACKGROUND: Non-Hodgkin lymphoma (NHL) of the breast is a rare disease and can occur amongst patients affected by Waldenström’s Macroglobulinemia (WM). WM is an indolent B-cell lymphoproliferative disorder with an overall incidence of about 1/100,000 in Europe. Breast imaging is not specific to brea...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AME Publishing Company
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080316/ https://www.ncbi.nlm.nih.gov/pubmed/37033363 http://dx.doi.org/10.21037/tcr-22-1893 |
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author | Esposito, Emanuela Varone, Valeria Siani, Claudio Di Bonito, Maurizio Melucci, Maria Teresa Donzelli, Ivana di Giacomo, Raimondo Marone, Ugo Saponara, Ruggero Collina, Francesca Fucito, Alfredo Avino, Franca |
author_facet | Esposito, Emanuela Varone, Valeria Siani, Claudio Di Bonito, Maurizio Melucci, Maria Teresa Donzelli, Ivana di Giacomo, Raimondo Marone, Ugo Saponara, Ruggero Collina, Francesca Fucito, Alfredo Avino, Franca |
author_sort | Esposito, Emanuela |
collection | PubMed |
description | BACKGROUND: Non-Hodgkin lymphoma (NHL) of the breast is a rare disease and can occur amongst patients affected by Waldenström’s Macroglobulinemia (WM). WM is an indolent B-cell lymphoproliferative disorder with an overall incidence of about 1/100,000 in Europe. Breast imaging is not specific to breast lymphoma that often mimics benign lesions. The diagnosis is based on breast biopsy, the presence of MYD88L265P somatic mutation and immunoglobulin M (IgM) paraprotein detectable in the setting of lymphoplasmacytic infiltration by bone marrow (BM) biopsy. CASE DESCRIPTION: A 60-year-old woman with personal and familial history of monoclonal gammopathy of undetermined significance (MGUS) and a lump in her right breast was referred to our hospital. Standard imaging showed round mass with smooth edges. The lump was biopsied and the pathology examination showed lymphoplasmacytic lymphoma (LPL) of the breast which led to final the diagnosis of WM. CONCLUSIONS: Lymphoma of the breast is a rare disease, often misdiagnosed because of the lack of specific features at mammogram and ultrasound. Core biopsy is crucial to make diagnosis of breast lymphoma and early diagnosis of WM has been shown to improve overall survival (OS). A comprehensive approach is required in order to assess patients affected by blood disorders presenting with a new breast mass that can lead to diagnosis of breast lymphoma. |
format | Online Article Text |
id | pubmed-10080316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-100803162023-04-08 B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report Esposito, Emanuela Varone, Valeria Siani, Claudio Di Bonito, Maurizio Melucci, Maria Teresa Donzelli, Ivana di Giacomo, Raimondo Marone, Ugo Saponara, Ruggero Collina, Francesca Fucito, Alfredo Avino, Franca Transl Cancer Res Case Report BACKGROUND: Non-Hodgkin lymphoma (NHL) of the breast is a rare disease and can occur amongst patients affected by Waldenström’s Macroglobulinemia (WM). WM is an indolent B-cell lymphoproliferative disorder with an overall incidence of about 1/100,000 in Europe. Breast imaging is not specific to breast lymphoma that often mimics benign lesions. The diagnosis is based on breast biopsy, the presence of MYD88L265P somatic mutation and immunoglobulin M (IgM) paraprotein detectable in the setting of lymphoplasmacytic infiltration by bone marrow (BM) biopsy. CASE DESCRIPTION: A 60-year-old woman with personal and familial history of monoclonal gammopathy of undetermined significance (MGUS) and a lump in her right breast was referred to our hospital. Standard imaging showed round mass with smooth edges. The lump was biopsied and the pathology examination showed lymphoplasmacytic lymphoma (LPL) of the breast which led to final the diagnosis of WM. CONCLUSIONS: Lymphoma of the breast is a rare disease, often misdiagnosed because of the lack of specific features at mammogram and ultrasound. Core biopsy is crucial to make diagnosis of breast lymphoma and early diagnosis of WM has been shown to improve overall survival (OS). A comprehensive approach is required in order to assess patients affected by blood disorders presenting with a new breast mass that can lead to diagnosis of breast lymphoma. AME Publishing Company 2023-03-07 2023-03-31 /pmc/articles/PMC10080316/ /pubmed/37033363 http://dx.doi.org/10.21037/tcr-22-1893 Text en 2023 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Case Report Esposito, Emanuela Varone, Valeria Siani, Claudio Di Bonito, Maurizio Melucci, Maria Teresa Donzelli, Ivana di Giacomo, Raimondo Marone, Ugo Saponara, Ruggero Collina, Francesca Fucito, Alfredo Avino, Franca B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title | B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title_full | B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title_fullStr | B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title_full_unstemmed | B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title_short | B-cell non-Hodgkin lymphoma of the breast in Waldenström’s macroglobulinemia: a case report |
title_sort | b-cell non-hodgkin lymphoma of the breast in waldenström’s macroglobulinemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080316/ https://www.ncbi.nlm.nih.gov/pubmed/37033363 http://dx.doi.org/10.21037/tcr-22-1893 |
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