Design, synthesis, and computational studies of novel imidazo[1,2-a]pyrimidine derivatives as potential dual inhibitors of hACE2 and spike protein for blocking SARS-CoV-2 cell entry

In the present work, a new series of imidazo[1,2-a]pyrimidine Schiff base derivatives have been obtained using an easy and conventional synthetic route. The synthesized compounds were spectroscopically characterized using (1)H, (13)C NMR, LC-MS(ESI), and FT-IR techniques. Green metric calculations i...

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Detalles Bibliográficos
Autores principales: Azzouzi, Mohamed, Ouafi, Zainab El, Azougagh, Omar, Daoudi, Walid, Ghazal, Hassan, Barkany, Soufian El, Abderrazak, Rfaki, Mazières, Stéphane, Aatiaoui, Abdelmalik El, Oussaid, Adyl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080474/
https://www.ncbi.nlm.nih.gov/pubmed/37057139
http://dx.doi.org/10.1016/j.molstruc.2023.135525

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