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Gastroesophageal reflux disease in children: What’s new right now?

Gastroesophageal reflux (GER) in children is very common and refers to the involuntary passage of gastric contents into the esophagus. This is often physiological and managed conservatively. In contrast, GER disease (GERD) is a less common pathologic process causing troublesome symptoms, which may n...

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Autores principales: Sintusek, Palittiya, Mutalib, Mohamed, Thapar, Nikhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080553/
https://www.ncbi.nlm.nih.gov/pubmed/37034973
http://dx.doi.org/10.4253/wjge.v15.i3.84
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author Sintusek, Palittiya
Mutalib, Mohamed
Thapar, Nikhil
author_facet Sintusek, Palittiya
Mutalib, Mohamed
Thapar, Nikhil
author_sort Sintusek, Palittiya
collection PubMed
description Gastroesophageal reflux (GER) in children is very common and refers to the involuntary passage of gastric contents into the esophagus. This is often physiological and managed conservatively. In contrast, GER disease (GERD) is a less common pathologic process causing troublesome symptoms, which may need medical management. Apart from abnormal transient relaxations of the lower esophageal sphincter, other factors that play a role in the pathogenesis of GERD include defects in esophageal mucosal defense, impaired esophageal and gastric motility and clearance, as well as anatomical defects of the lower esophageal reflux barrier such as hiatal hernia. The clinical manifestations of GERD in young children are varied and nonspecific prompting the necessity for careful diagnostic evaluation. Management should be targeted to the underlying aetiopathogenesis and to limit complications of GERD. The following review focuses on up-to-date information regarding of the pathogenesis, diagnostic evaluation and management of GERD in children.
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spelling pubmed-100805532023-04-08 Gastroesophageal reflux disease in children: What’s new right now? Sintusek, Palittiya Mutalib, Mohamed Thapar, Nikhil World J Gastrointest Endosc Review Gastroesophageal reflux (GER) in children is very common and refers to the involuntary passage of gastric contents into the esophagus. This is often physiological and managed conservatively. In contrast, GER disease (GERD) is a less common pathologic process causing troublesome symptoms, which may need medical management. Apart from abnormal transient relaxations of the lower esophageal sphincter, other factors that play a role in the pathogenesis of GERD include defects in esophageal mucosal defense, impaired esophageal and gastric motility and clearance, as well as anatomical defects of the lower esophageal reflux barrier such as hiatal hernia. The clinical manifestations of GERD in young children are varied and nonspecific prompting the necessity for careful diagnostic evaluation. Management should be targeted to the underlying aetiopathogenesis and to limit complications of GERD. The following review focuses on up-to-date information regarding of the pathogenesis, diagnostic evaluation and management of GERD in children. Baishideng Publishing Group Inc 2023-03-16 2023-03-16 /pmc/articles/PMC10080553/ /pubmed/37034973 http://dx.doi.org/10.4253/wjge.v15.i3.84 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Sintusek, Palittiya
Mutalib, Mohamed
Thapar, Nikhil
Gastroesophageal reflux disease in children: What’s new right now?
title Gastroesophageal reflux disease in children: What’s new right now?
title_full Gastroesophageal reflux disease in children: What’s new right now?
title_fullStr Gastroesophageal reflux disease in children: What’s new right now?
title_full_unstemmed Gastroesophageal reflux disease in children: What’s new right now?
title_short Gastroesophageal reflux disease in children: What’s new right now?
title_sort gastroesophageal reflux disease in children: what’s new right now?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080553/
https://www.ncbi.nlm.nih.gov/pubmed/37034973
http://dx.doi.org/10.4253/wjge.v15.i3.84
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