Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen–Deuterium Exchange Mass Spectrometry

[Image: see text] Hydrogen–deuterium exchange mass spectrometry (HDX-MS) is a method to probe the solvent accessibility and conformational dynamics of a protein or a protein–ligand complex with respect to exchangeable amide hydrogens. Here, we present the application of HDX-MS to determine the bindi...

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Detalles Bibliográficos
Autores principales: Olaleye, Oladapo, Graf, Christian, Spanov, Baubek, Govorukhina, Natalia, Groves, Matthew R., van de Merbel, Nico C., Bischoff, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080681/
https://www.ncbi.nlm.nih.gov/pubmed/36960982
http://dx.doi.org/10.1021/jasms.3c00069

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