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Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase

[Image: see text] KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytically labile covalent acyl-enzyme in...

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Detalles Bibliográficos
Autores principales:	Tooke, Catherine L., Hinchliffe, Philip, Beer, Michael, Zinovjev, Kirill, Colenso, Charlotte K., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080687/ https://www.ncbi.nlm.nih.gov/pubmed/36972204 http://dx.doi.org/10.1021/jacs.2c12123

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