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Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study
BACKGROUND: Lugol chromoendoscopy (LCE) has served as a standard screening technique in high-risk patients with esophageal cancer. Nevertheless, LCE is not suitable for general population screening given its side effects. Linked color imaging (LCI) is a novel image-enhanced endoscopic technique that...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080703/ https://www.ncbi.nlm.nih.gov/pubmed/37032726 http://dx.doi.org/10.3748/wjg.v29.i12.1899 |
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author | Wang, Zi-Xin Li, Long-Song Su, Song Li, Jin-Ping Zhang, Bo Wang, Nan-Jun Liu, Sheng-Zhen Wang, Sha-Sha Zhang, Shuai Bi, Ya-Wei Gao, Fei Shao, Qun Xu, Ning Shao, Bo-Zong Yao, Yi Liu, Fang Linghu, En-Qiang Chai, Ning-Li |
author_facet | Wang, Zi-Xin Li, Long-Song Su, Song Li, Jin-Ping Zhang, Bo Wang, Nan-Jun Liu, Sheng-Zhen Wang, Sha-Sha Zhang, Shuai Bi, Ya-Wei Gao, Fei Shao, Qun Xu, Ning Shao, Bo-Zong Yao, Yi Liu, Fang Linghu, En-Qiang Chai, Ning-Li |
author_sort | Wang, Zi-Xin |
collection | PubMed |
description | BACKGROUND: Lugol chromoendoscopy (LCE) has served as a standard screening technique in high-risk patients with esophageal cancer. Nevertheless, LCE is not suitable for general population screening given its side effects. Linked color imaging (LCI) is a novel image-enhanced endoscopic technique that can distinguish subtle diff-erences in mucosal color. AIM: To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions. METHODS: In this prospective study, we enrolled 543 patients who underwent white light imaging (WLI), LCI and LCE successively. We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions. Clinicopathological features and color analysis of lesions were assessed. RESULTS: In total, 43 patients (45 neoplastic lesions) were analyzed. Among them, 36 patients (38 neoplastic lesions) were diagnosed with LCI, and 39 patients (41 neoplastic lesions) were diagnosed with LCE. The sensitivity of LCI was similar to that of LCE (83.7% vs 90.7%, P = 0.520), whereas the specificity of LCI was greater than that of LCE (92.4% vs 87.0%, P = 0.007). The LCI procedure time in the esophageal examination was significantly shorter than that of LCE [42 (34, 50) s vs 160 (130, 189) s, P < 0.001]. The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI. However, the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer. CONCLUSION: LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions, and LCI represents a promising screening strategy for general populations. |
format | Online Article Text |
id | pubmed-10080703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-100807032023-04-08 Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study Wang, Zi-Xin Li, Long-Song Su, Song Li, Jin-Ping Zhang, Bo Wang, Nan-Jun Liu, Sheng-Zhen Wang, Sha-Sha Zhang, Shuai Bi, Ya-Wei Gao, Fei Shao, Qun Xu, Ning Shao, Bo-Zong Yao, Yi Liu, Fang Linghu, En-Qiang Chai, Ning-Li World J Gastroenterol Clinical Trials Study BACKGROUND: Lugol chromoendoscopy (LCE) has served as a standard screening technique in high-risk patients with esophageal cancer. Nevertheless, LCE is not suitable for general population screening given its side effects. Linked color imaging (LCI) is a novel image-enhanced endoscopic technique that can distinguish subtle diff-erences in mucosal color. AIM: To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions. METHODS: In this prospective study, we enrolled 543 patients who underwent white light imaging (WLI), LCI and LCE successively. We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions. Clinicopathological features and color analysis of lesions were assessed. RESULTS: In total, 43 patients (45 neoplastic lesions) were analyzed. Among them, 36 patients (38 neoplastic lesions) were diagnosed with LCI, and 39 patients (41 neoplastic lesions) were diagnosed with LCE. The sensitivity of LCI was similar to that of LCE (83.7% vs 90.7%, P = 0.520), whereas the specificity of LCI was greater than that of LCE (92.4% vs 87.0%, P = 0.007). The LCI procedure time in the esophageal examination was significantly shorter than that of LCE [42 (34, 50) s vs 160 (130, 189) s, P < 0.001]. The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI. However, the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer. CONCLUSION: LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions, and LCI represents a promising screening strategy for general populations. Baishideng Publishing Group Inc 2023-03-28 2023-03-28 /pmc/articles/PMC10080703/ /pubmed/37032726 http://dx.doi.org/10.3748/wjg.v29.i12.1899 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Clinical Trials Study Wang, Zi-Xin Li, Long-Song Su, Song Li, Jin-Ping Zhang, Bo Wang, Nan-Jun Liu, Sheng-Zhen Wang, Sha-Sha Zhang, Shuai Bi, Ya-Wei Gao, Fei Shao, Qun Xu, Ning Shao, Bo-Zong Yao, Yi Liu, Fang Linghu, En-Qiang Chai, Ning-Li Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title | Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title_full | Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title_fullStr | Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title_full_unstemmed | Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title_short | Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study |
title_sort | linked color imaging vs lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: a noninferiority study |
topic | Clinical Trials Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080703/ https://www.ncbi.nlm.nih.gov/pubmed/37032726 http://dx.doi.org/10.3748/wjg.v29.i12.1899 |
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