Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice

N(6)-methyladenosine (m(6)A) modification has been shown to regulate RNA metabolism. Here, we investigate m(6)A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m(6)A can be maternally inherited or de novo gained after fertilization. Int...

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Detalles Bibliográficos
Autores principales: Zhu, Wencheng, Ding, Yufeng, Meng, Juan, Gu, Lei, Liu, Wenjun, Li, Li, Chen, Hongyu, Wang, Yining, Li, Ziyi, Li, Chen, Sun, Yidi, Liu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080794/
https://www.ncbi.nlm.nih.gov/pubmed/37024923
http://dx.doi.org/10.1186/s13059-023-02918-9
Descripción
Sumario:N(6)-methyladenosine (m(6)A) modification has been shown to regulate RNA metabolism. Here, we investigate m(6)A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m(6)A can be maternally inherited or de novo gained after fertilization. Interestingly, m(6)A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m(6)A readers for mouse preimplantation development. Our study reveals a key role of m(6)A mediated RNA metabolism during MZT in mammals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-02918-9.

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