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Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice

N(6)-methyladenosine (m(6)A) modification has been shown to regulate RNA metabolism. Here, we investigate m(6)A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m(6)A can be maternally inherited or de novo gained after fertilization. Int...

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Autores principales: Zhu, Wencheng, Ding, Yufeng, Meng, Juan, Gu, Lei, Liu, Wenjun, Li, Li, Chen, Hongyu, Wang, Yining, Li, Ziyi, Li, Chen, Sun, Yidi, Liu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080794/
https://www.ncbi.nlm.nih.gov/pubmed/37024923
http://dx.doi.org/10.1186/s13059-023-02918-9
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author Zhu, Wencheng
Ding, Yufeng
Meng, Juan
Gu, Lei
Liu, Wenjun
Li, Li
Chen, Hongyu
Wang, Yining
Li, Ziyi
Li, Chen
Sun, Yidi
Liu, Zhen
author_facet Zhu, Wencheng
Ding, Yufeng
Meng, Juan
Gu, Lei
Liu, Wenjun
Li, Li
Chen, Hongyu
Wang, Yining
Li, Ziyi
Li, Chen
Sun, Yidi
Liu, Zhen
author_sort Zhu, Wencheng
collection PubMed
description N(6)-methyladenosine (m(6)A) modification has been shown to regulate RNA metabolism. Here, we investigate m(6)A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m(6)A can be maternally inherited or de novo gained after fertilization. Interestingly, m(6)A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m(6)A readers for mouse preimplantation development. Our study reveals a key role of m(6)A mediated RNA metabolism during MZT in mammals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-02918-9.
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spelling pubmed-100807942023-04-08 Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice Zhu, Wencheng Ding, Yufeng Meng, Juan Gu, Lei Liu, Wenjun Li, Li Chen, Hongyu Wang, Yining Li, Ziyi Li, Chen Sun, Yidi Liu, Zhen Genome Biol Short Report N(6)-methyladenosine (m(6)A) modification has been shown to regulate RNA metabolism. Here, we investigate m(6)A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m(6)A can be maternally inherited or de novo gained after fertilization. Interestingly, m(6)A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m(6)A readers for mouse preimplantation development. Our study reveals a key role of m(6)A mediated RNA metabolism during MZT in mammals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-02918-9. BioMed Central 2023-04-06 /pmc/articles/PMC10080794/ /pubmed/37024923 http://dx.doi.org/10.1186/s13059-023-02918-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Zhu, Wencheng
Ding, Yufeng
Meng, Juan
Gu, Lei
Liu, Wenjun
Li, Li
Chen, Hongyu
Wang, Yining
Li, Ziyi
Li, Chen
Sun, Yidi
Liu, Zhen
Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title_full Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title_fullStr Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title_full_unstemmed Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title_short Reading and writing of mRNA m(6)A modification orchestrate maternal-to-zygotic transition in mice
title_sort reading and writing of mrna m(6)a modification orchestrate maternal-to-zygotic transition in mice
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080794/
https://www.ncbi.nlm.nih.gov/pubmed/37024923
http://dx.doi.org/10.1186/s13059-023-02918-9
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