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Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre

BACKGROUND: Gastroenteropancreatic Neuroendocrine tumors (GEP-NET) are rare neoplasms with limited reported data from the Middle East. Our study aims to report the clinicopathological feature, treatment patterns, and survival outcomes of patients with GEP-NET from our part of the world. METHODS: Med...

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Autores principales: Bazarbashi, Shouki, Aseafan, Mohamed, Elgazzar, Tasnim, Alkhayat, Maha, Alghabban, Abdulrahman, Abdelgawad, Marwa I., Alshamsan, Bader, Alshibany, Aisha, Elhassan, Tusneem, Aljubran, Ali, Alzahrani, Ahmed, Alhindi, Hindi, Raef, Hussein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080845/
https://www.ncbi.nlm.nih.gov/pubmed/37029347
http://dx.doi.org/10.1186/s12902-023-01326-1
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author Bazarbashi, Shouki
Aseafan, Mohamed
Elgazzar, Tasnim
Alkhayat, Maha
Alghabban, Abdulrahman
Abdelgawad, Marwa I.
Alshamsan, Bader
Alshibany, Aisha
Elhassan, Tusneem
Aljubran, Ali
Alzahrani, Ahmed
Alhindi, Hindi
Raef, Hussein
author_facet Bazarbashi, Shouki
Aseafan, Mohamed
Elgazzar, Tasnim
Alkhayat, Maha
Alghabban, Abdulrahman
Abdelgawad, Marwa I.
Alshamsan, Bader
Alshibany, Aisha
Elhassan, Tusneem
Aljubran, Ali
Alzahrani, Ahmed
Alhindi, Hindi
Raef, Hussein
author_sort Bazarbashi, Shouki
collection PubMed
description BACKGROUND: Gastroenteropancreatic Neuroendocrine tumors (GEP-NET) are rare neoplasms with limited reported data from the Middle East. Our study aims to report the clinicopathological feature, treatment patterns, and survival outcomes of patients with GEP-NET from our part of the world. METHODS: Medical records of patients diagnosed with GEP-NET between January 2011 and December 2016 at a single center in Saudi Arabia were reviewed retrospectively, and complete clinicopathological and treatment data were collected. Patients’ survival was estimated by the Kaplan–Meier method. RESULTS: A total of 72 patients were identified with a median age of 51 years (range 27–82) and male-to-female ratio of (1.1). The most common tumor location was the pancreas (29.1%), followed by small bowel (25%), stomach (12.5%), rectum (8.3%), colon (8.3%), and appendix (6.9%). Forty-one patients (57%) had well-differentiated grade (G)1, 21 (29%) had G2, and 4 (6%) had G3. In five patients, the pathology was neuroendocrine carcinoma and in one it could not be classified. 54.2% of the patients were metastatic at diagnosis. Forty-two patients underwent surgical resection as primary management while 26 underwent systemic therapy, three patients were put on active surveillance, and one was treated endoscopically with polypectomy. The 5-year overall survival and progression-free survivals were 77.2% and 49%, respectively, for the whole group. Patients with G1 and 2 disease, lower Ki-67 index, and surgically treated as primary management had significantly better survival outcomes. CONCLUSION: Our study suggests that the most common tumor locations are similar to western reported data. However, there seems to be a higher incidence of metastatic disease at presentation than in the rest of the world.
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spelling pubmed-100808452023-04-08 Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre Bazarbashi, Shouki Aseafan, Mohamed Elgazzar, Tasnim Alkhayat, Maha Alghabban, Abdulrahman Abdelgawad, Marwa I. Alshamsan, Bader Alshibany, Aisha Elhassan, Tusneem Aljubran, Ali Alzahrani, Ahmed Alhindi, Hindi Raef, Hussein BMC Endocr Disord Research Article BACKGROUND: Gastroenteropancreatic Neuroendocrine tumors (GEP-NET) are rare neoplasms with limited reported data from the Middle East. Our study aims to report the clinicopathological feature, treatment patterns, and survival outcomes of patients with GEP-NET from our part of the world. METHODS: Medical records of patients diagnosed with GEP-NET between January 2011 and December 2016 at a single center in Saudi Arabia were reviewed retrospectively, and complete clinicopathological and treatment data were collected. Patients’ survival was estimated by the Kaplan–Meier method. RESULTS: A total of 72 patients were identified with a median age of 51 years (range 27–82) and male-to-female ratio of (1.1). The most common tumor location was the pancreas (29.1%), followed by small bowel (25%), stomach (12.5%), rectum (8.3%), colon (8.3%), and appendix (6.9%). Forty-one patients (57%) had well-differentiated grade (G)1, 21 (29%) had G2, and 4 (6%) had G3. In five patients, the pathology was neuroendocrine carcinoma and in one it could not be classified. 54.2% of the patients were metastatic at diagnosis. Forty-two patients underwent surgical resection as primary management while 26 underwent systemic therapy, three patients were put on active surveillance, and one was treated endoscopically with polypectomy. The 5-year overall survival and progression-free survivals were 77.2% and 49%, respectively, for the whole group. Patients with G1 and 2 disease, lower Ki-67 index, and surgically treated as primary management had significantly better survival outcomes. CONCLUSION: Our study suggests that the most common tumor locations are similar to western reported data. However, there seems to be a higher incidence of metastatic disease at presentation than in the rest of the world. BioMed Central 2023-04-07 /pmc/articles/PMC10080845/ /pubmed/37029347 http://dx.doi.org/10.1186/s12902-023-01326-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Bazarbashi, Shouki
Aseafan, Mohamed
Elgazzar, Tasnim
Alkhayat, Maha
Alghabban, Abdulrahman
Abdelgawad, Marwa I.
Alshamsan, Bader
Alshibany, Aisha
Elhassan, Tusneem
Aljubran, Ali
Alzahrani, Ahmed
Alhindi, Hindi
Raef, Hussein
Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title_full Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title_fullStr Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title_full_unstemmed Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title_short Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
title_sort characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080845/
https://www.ncbi.nlm.nih.gov/pubmed/37029347
http://dx.doi.org/10.1186/s12902-023-01326-1
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