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Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus

Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrP(C),) resulting in the activation of macromolecular complexes and signalin...

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Detalles Bibliográficos
Autores principales:	Ojeda-Juárez, Daniel, Lawrence, Jessica A., Soldau, Katrin, Pizzo, Donald P., Wheeler, Emily, Aguilar-Calvo, Patricia, Khuu, Helen, Chen, Joy, Malik, Adela, Funk, Gail, Nam, Percival, Sanchez, Henry, Geschwind, Michael D., Wu, Chengbiao, Yeo, Gene W., Chen, Xu, Patrick, Gentry N., Sigurdson, Christina J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080886/ https://www.ncbi.nlm.nih.gov/pubmed/35905927 http://dx.doi.org/10.1016/j.nbd.2022.105834

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