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Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 par...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish Society of Gastroenterology
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081027/ https://www.ncbi.nlm.nih.gov/pubmed/36445049 http://dx.doi.org/10.5152/tjg.2022.21929 |
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author | Guo, Maodong Ye, Xiaohua Shi, Xin |
author_facet | Guo, Maodong Ye, Xiaohua Shi, Xin |
author_sort | Guo, Maodong |
collection | PubMed |
description | BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 participants aged ≥ 20 years from the National Health and Nutritional Survey (2003-2006). Non-alcoholic fatty liver disease was defined as the US Fatty Liver Index ≥ 30 in the absence of other chronic liver disease. Multivariate logistic regression and the fitted smoothing curves were adopted for analyzing the correlation between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. RESULTS: After adjusting for all the covariates, it was discovered that serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease (odds ratio: 0.664, 95% CI: 0.512-0.860, P = .002). Through smooth curve fitting, it was further noticed that the relationship between serum vitamin C and the risk of non-alcoholic fatty liver disease was non-linear. The inflection point was 0.92, and to its left, a negative correlation was seen between vitamin C and non-alcoholic fatty liver disease (odds ratio: 0.451, 95% CI: 0.288-0.706, P = .001). To the right of the inflection point, however, the correlation between vitamin C and non-alcoholic fatty liver disease was not found to be significant. CONCLUSION: The correlation was non-linear between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. Serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease when its level was less than 0.92 mg/dL. |
format | Online Article Text |
id | pubmed-10081027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Turkish Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-100810272023-04-08 Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study Guo, Maodong Ye, Xiaohua Shi, Xin Turk J Gastroenterol Original Article BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 participants aged ≥ 20 years from the National Health and Nutritional Survey (2003-2006). Non-alcoholic fatty liver disease was defined as the US Fatty Liver Index ≥ 30 in the absence of other chronic liver disease. Multivariate logistic regression and the fitted smoothing curves were adopted for analyzing the correlation between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. RESULTS: After adjusting for all the covariates, it was discovered that serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease (odds ratio: 0.664, 95% CI: 0.512-0.860, P = .002). Through smooth curve fitting, it was further noticed that the relationship between serum vitamin C and the risk of non-alcoholic fatty liver disease was non-linear. The inflection point was 0.92, and to its left, a negative correlation was seen between vitamin C and non-alcoholic fatty liver disease (odds ratio: 0.451, 95% CI: 0.288-0.706, P = .001). To the right of the inflection point, however, the correlation between vitamin C and non-alcoholic fatty liver disease was not found to be significant. CONCLUSION: The correlation was non-linear between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. Serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease when its level was less than 0.92 mg/dL. Turkish Society of Gastroenterology 2023-02-01 /pmc/articles/PMC10081027/ /pubmed/36445049 http://dx.doi.org/10.5152/tjg.2022.21929 Text en 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Original Article Guo, Maodong Ye, Xiaohua Shi, Xin Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title | Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title_full | Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title_fullStr | Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title_full_unstemmed | Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title_short | Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study |
title_sort | association between serum vitamin c and non-alcoholic fatty liver disease: a cross-sectional study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081027/ https://www.ncbi.nlm.nih.gov/pubmed/36445049 http://dx.doi.org/10.5152/tjg.2022.21929 |
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