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Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study

BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 par...

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Autores principales: Guo, Maodong, Ye, Xiaohua, Shi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081027/
https://www.ncbi.nlm.nih.gov/pubmed/36445049
http://dx.doi.org/10.5152/tjg.2022.21929
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author Guo, Maodong
Ye, Xiaohua
Shi, Xin
author_facet Guo, Maodong
Ye, Xiaohua
Shi, Xin
author_sort Guo, Maodong
collection PubMed
description BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 participants aged ≥ 20 years from the National Health and Nutritional Survey (2003-2006). Non-alcoholic fatty liver disease was defined as the US Fatty Liver Index ≥ 30 in the absence of other chronic liver disease. Multivariate logistic regression and the fitted smoothing curves were adopted for analyzing the correlation between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. RESULTS: After adjusting for all the covariates, it was discovered that serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease (odds ratio: 0.664, 95% CI: 0.512-0.860, P = .002). Through smooth curve fitting, it was further noticed that the relationship between serum vitamin C and the risk of non-alcoholic fatty liver disease was non-linear. The inflection point was 0.92, and to its left, a negative correlation was seen between vitamin C and non-alcoholic fatty liver disease (odds ratio: 0.451, 95% CI: 0.288-0.706, P = .001). To the right of the inflection point, however, the correlation between vitamin C and non-alcoholic fatty liver disease was not found to be significant. CONCLUSION: The correlation was non-linear between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. Serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease when its level was less than 0.92 mg/dL.
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spelling pubmed-100810272023-04-08 Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study Guo, Maodong Ye, Xiaohua Shi, Xin Turk J Gastroenterol Original Article BACKGROUND: The association between vitamin C and the risk of developing non-alcoholic fatty liver disease remains controversial. The aim of the present study is to examine any correlation between serum vitamin C and the risk of non-alcoholic fatty liver disease. METHODS: Our study enrolled 3374 participants aged ≥ 20 years from the National Health and Nutritional Survey (2003-2006). Non-alcoholic fatty liver disease was defined as the US Fatty Liver Index ≥ 30 in the absence of other chronic liver disease. Multivariate logistic regression and the fitted smoothing curves were adopted for analyzing the correlation between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. RESULTS: After adjusting for all the covariates, it was discovered that serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease (odds ratio: 0.664, 95% CI: 0.512-0.860, P = .002). Through smooth curve fitting, it was further noticed that the relationship between serum vitamin C and the risk of non-alcoholic fatty liver disease was non-linear. The inflection point was 0.92, and to its left, a negative correlation was seen between vitamin C and non-alcoholic fatty liver disease (odds ratio: 0.451, 95% CI: 0.288-0.706, P = .001). To the right of the inflection point, however, the correlation between vitamin C and non-alcoholic fatty liver disease was not found to be significant. CONCLUSION: The correlation was non-linear between serum vitamin C levels and the risk of developing non-alcoholic fatty liver disease. Serum vitamin C was negatively correlated with the risk of non-alcoholic fatty liver disease when its level was less than 0.92 mg/dL. Turkish Society of Gastroenterology 2023-02-01 /pmc/articles/PMC10081027/ /pubmed/36445049 http://dx.doi.org/10.5152/tjg.2022.21929 Text en 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Guo, Maodong
Ye, Xiaohua
Shi, Xin
Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title_full Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title_fullStr Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title_full_unstemmed Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title_short Association Between Serum Vitamin C and Non-alcoholic Fatty Liver Disease: A Cross-sectional Study
title_sort association between serum vitamin c and non-alcoholic fatty liver disease: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081027/
https://www.ncbi.nlm.nih.gov/pubmed/36445049
http://dx.doi.org/10.5152/tjg.2022.21929
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