Succesful Use of Lipid Emulsion Theraphy in a Case of Extremely High-Dose Olanzapine Intoxication

In olanzapine intoxication, alterations in consciousness defined as “agitation despite sedation,” as well as cardiovascular and extrapyramidal side effects due to anticholinergic effects, can be seen. In this case report, we aimed to present a patient who took a very high dose of olanzapine for suicide purposes and later benefitted from intravenous lipid emulsion treatment. A 20-year-old male patient, who took 840 mg of olanzapine for suicide, was brought to the emergency room, and when the Glasgow Coma Scale was 5, he was intubated and given a single dose of activated charcoal. Later, he was admitted to the intensive care unit and was intubated. The olanzapine level was measured as 653 μg L(−1). The patient was started on lipid emulsion treatment and woke up in the sixth hour. In addition to the lack of strong evidence regarding the use of lipid emulsion treatment in olanzapine intoxication, it is seen that lipid therapy has been used successfully in patients. Compared with the cases in the literature, lipid emulsion treatment was successfully applied in our case, where the blood olanzapine level was very high. Although there is no evidence-based treatment for olanzapine intoxication, we believe that lipid emulsion treatment has a positive effect on neurological recovery and survival.