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Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis

Objectives: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. Methods: A systematic literature search was conducted in PubMed and...

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Autores principales: Zhang, Jialing, Pang, Qi, Zhou, Ting, Meng, Jiali, Dong, Xingtong, Wang, Zhe, Zhang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081062/
https://www.ncbi.nlm.nih.gov/pubmed/37021610
http://dx.doi.org/10.1080/0886022X.2023.2170809
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author Zhang, Jialing
Pang, Qi
Zhou, Ting
Meng, Jiali
Dong, Xingtong
Wang, Zhe
Zhang, Aihua
author_facet Zhang, Jialing
Pang, Qi
Zhou, Ting
Meng, Jiali
Dong, Xingtong
Wang, Zhe
Zhang, Aihua
author_sort Zhang, Jialing
collection PubMed
description Objectives: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. Methods: A systematic literature search was conducted in PubMed and EMBASE from 1 December 2019 to 1 January 2023. Due to significant study heterogeneity, meta-analyses were conducted using random-effects models. Meta-regression and sensitivity analysis were also performed. Results: A total of 153,600 COVID-19 patients from 39 studies were included, and 28,003 patients developed AKI. By meta-analysis, we discovered that age, male sex, obesity, black race, invasive ventilation, and the use of diuretics, steroids and vasopressors, in addition to comorbidities such as hypertension, congestive heart failure, chronic kidney disease, acute respiratory distress syndrome, and diabetes, were significant risk factors for COVID-19-associated AKI. Conclusions: Early detection of these risk factors is essential to reduce the incidence of AKI and improve the prognosis of COVID-19 patients.
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spelling pubmed-100810622023-04-08 Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis Zhang, Jialing Pang, Qi Zhou, Ting Meng, Jiali Dong, Xingtong Wang, Zhe Zhang, Aihua Ren Fail State-of-the-Art Review Objectives: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. Methods: A systematic literature search was conducted in PubMed and EMBASE from 1 December 2019 to 1 January 2023. Due to significant study heterogeneity, meta-analyses were conducted using random-effects models. Meta-regression and sensitivity analysis were also performed. Results: A total of 153,600 COVID-19 patients from 39 studies were included, and 28,003 patients developed AKI. By meta-analysis, we discovered that age, male sex, obesity, black race, invasive ventilation, and the use of diuretics, steroids and vasopressors, in addition to comorbidities such as hypertension, congestive heart failure, chronic kidney disease, acute respiratory distress syndrome, and diabetes, were significant risk factors for COVID-19-associated AKI. Conclusions: Early detection of these risk factors is essential to reduce the incidence of AKI and improve the prognosis of COVID-19 patients. Taylor & Francis 2023-04-06 /pmc/articles/PMC10081062/ /pubmed/37021610 http://dx.doi.org/10.1080/0886022X.2023.2170809 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle State-of-the-Art Review
Zhang, Jialing
Pang, Qi
Zhou, Ting
Meng, Jiali
Dong, Xingtong
Wang, Zhe
Zhang, Aihua
Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title_full Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title_fullStr Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title_full_unstemmed Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title_short Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
title_sort risk factors for acute kidney injury in covid-19 patients: an updated systematic review and meta-analysis
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081062/
https://www.ncbi.nlm.nih.gov/pubmed/37021610
http://dx.doi.org/10.1080/0886022X.2023.2170809
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