Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights

Since April 2022, over 1000 children across 35 countries have developed episodes of acute hepatitis of unknown origin. At King’s College Hospital, a total of 65 children were referred with acute hepatitis of unknown etiology, with 10 of these children presenting with acute liver dysfunction leading...

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Autores principales: Vimalesvaran, Sunitha, Verma, Anita, Kyrana, Eirini, Deheragoda, Maesha, Dhawan, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081105/
https://www.ncbi.nlm.nih.gov/pubmed/36788593
http://dx.doi.org/10.1093/cei/uxad023
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author Vimalesvaran, Sunitha
Verma, Anita
Kyrana, Eirini
Deheragoda, Maesha
Dhawan, Anil
author_facet Vimalesvaran, Sunitha
Verma, Anita
Kyrana, Eirini
Deheragoda, Maesha
Dhawan, Anil
author_sort Vimalesvaran, Sunitha
collection PubMed
description Since April 2022, over 1000 children across 35 countries have developed episodes of acute hepatitis of unknown origin. At King’s College Hospital, a total of 65 children were referred with acute hepatitis of unknown etiology, with 10 of these children presenting with acute liver dysfunction leading to acute liver failure. Multiple hypotheses have been proposed and continue to be investigated worldwide. In this review, we explore the current understanding of potential aetiologies for this outbreak. We further characterize the proposed immunological mechanisms of liver injury in these cases.
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spelling pubmed-100811052023-04-08 Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights Vimalesvaran, Sunitha Verma, Anita Kyrana, Eirini Deheragoda, Maesha Dhawan, Anil Clin Exp Immunol Review Since April 2022, over 1000 children across 35 countries have developed episodes of acute hepatitis of unknown origin. At King’s College Hospital, a total of 65 children were referred with acute hepatitis of unknown etiology, with 10 of these children presenting with acute liver dysfunction leading to acute liver failure. Multiple hypotheses have been proposed and continue to be investigated worldwide. In this review, we explore the current understanding of potential aetiologies for this outbreak. We further characterize the proposed immunological mechanisms of liver injury in these cases. Oxford University Press 2023-02-15 /pmc/articles/PMC10081105/ /pubmed/36788593 http://dx.doi.org/10.1093/cei/uxad023 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Vimalesvaran, Sunitha
Verma, Anita
Kyrana, Eirini
Deheragoda, Maesha
Dhawan, Anil
Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title_full Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title_fullStr Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title_full_unstemmed Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title_short Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
title_sort acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081105/
https://www.ncbi.nlm.nih.gov/pubmed/36788593
http://dx.doi.org/10.1093/cei/uxad023
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