Activity-dependent constraints on catecholamine signaling

Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High t...

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Detalles Bibliográficos
Autores principales: Li, Li, Rana, Akshay, Li, Esther M., Feng, Jiesi, Li, Yulong, Bruchas, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081217/
https://www.ncbi.nlm.nih.gov/pubmed/37034631
http://dx.doi.org/10.1101/2023.03.30.534970
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author Li, Li
Rana, Akshay
Li, Esther M.
Feng, Jiesi
Li, Yulong
Bruchas, Michael R.
author_facet Li, Li
Rana, Akshay
Li, Esther M.
Feng, Jiesi
Li, Yulong
Bruchas, Michael R.
author_sort Li, Li
collection PubMed
description Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together this provides a clearer understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.
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spelling pubmed-100812172023-04-08 Activity-dependent constraints on catecholamine signaling Li, Li Rana, Akshay Li, Esther M. Feng, Jiesi Li, Yulong Bruchas, Michael R. bioRxiv Article Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together this provides a clearer understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling. Cold Spring Harbor Laboratory 2023-03-31 /pmc/articles/PMC10081217/ /pubmed/37034631 http://dx.doi.org/10.1101/2023.03.30.534970 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Li, Li
Rana, Akshay
Li, Esther M.
Feng, Jiesi
Li, Yulong
Bruchas, Michael R.
Activity-dependent constraints on catecholamine signaling
title Activity-dependent constraints on catecholamine signaling
title_full Activity-dependent constraints on catecholamine signaling
title_fullStr Activity-dependent constraints on catecholamine signaling
title_full_unstemmed Activity-dependent constraints on catecholamine signaling
title_short Activity-dependent constraints on catecholamine signaling
title_sort activity-dependent constraints on catecholamine signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081217/
https://www.ncbi.nlm.nih.gov/pubmed/37034631
http://dx.doi.org/10.1101/2023.03.30.534970
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