BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels

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Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modifications likely contributes to disease states and cancer. Depletion of the chromatin-binding protein BRWD3, a known substrate-specificity factor of the Cul4-DDB1 E3 ubiquitin liga...

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Detalles Bibliográficos
Autores principales: Han, Dongsheng, Schaffner, Samantha H., Davies, Jonathan P., Lauren Benton, Mary, Plate, Lars, Nordman, Jared T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081218/
https://www.ncbi.nlm.nih.gov/pubmed/37034668
http://dx.doi.org/10.1101/2023.03.28.534572

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