HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance

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Stimulation of adipocyte β-adrenergic receptors (β-ARs) induces expression of uncoupling protein 1 (UCP1), promoting non-shivering thermogenesis. Association of β-ARs with a lysine myristoylated form of A-kinase anchoring protein 12 (AKAP12)/gravin-α is required for downstream signaling that culmina...

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Detalles Bibliográficos
Autores principales: Robinson, Emma L., Bagchi, Rushita A., Major, Jennifer L., Bergman, Bryan C., Madsuda, Jennifer L., McKinsey, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081236/
https://www.ncbi.nlm.nih.gov/pubmed/37034582
http://dx.doi.org/10.1101/2023.03.29.534830
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