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Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

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Catalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) are a family of microtubule-as...

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Detalles Bibliográficos
Autores principales:	Venkat, Aarya, Watterson, Grace, Byrne, Dominic P., O’Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E., Daly, Leonard A., Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E., Eyers, Patrick A., Kannan, Natarajan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081240/ https://www.ncbi.nlm.nih.gov/pubmed/37034755 http://dx.doi.org/10.1101/2023.03.29.534689

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