Splicing accuracy varies across human introns, tissues and age

Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigated mis-splicing using RNA-sequencing data from ~14K control samples and 42 human body sites, focusing on split reads partially mapping to...

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Detalles Bibliográficos
Autores principales: García-Ruiz, S, Zhang, D, Gustavsson, E K, Rocamora-Perez, G, Grant-Peters, M, Fairbrother-Browne, A, Reynolds, R H, Brenton, J W, Gil-Martínez, A L, Chen, Z, Rio, D C, Botia, J A, Guelfi, S, Collado-Torres, L, Ryten, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081249/
https://www.ncbi.nlm.nih.gov/pubmed/37034741
http://dx.doi.org/10.1101/2023.03.29.534370

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