β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

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The vasopressin type 2 receptor (V(2)R) is an essential GPCR in renal regulation of water homeostasis. Upon stimulation, the V(2)R activates Gα(s) and Gα(q/11), which is followed by robust recruitment of β-arrestins and receptor internalization into endosomes. Unlike canonical GPCR signaling, the β-...

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Detalles Bibliográficos
Autores principales: Daly, Carole, Guseinov, Akim Abdul, Hahn, Hyunggu, Wright, Adam, Tikhonova, Irina G., Thomsen, Alex Rojas Bie, Plouffe, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081317/
https://www.ncbi.nlm.nih.gov/pubmed/37034816
http://dx.doi.org/10.1101/2023.04.01.535208
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