Heparan sulfate promotes ACE2 super-cluster assembly to enhance SARS-CoV-2-associated syncytium formation

The mechanism of syncytium formation, caused by spike-induced cell-cell fusion in severe COVID-19, is largely unclear. Here we combine chemical genetics with 4D confocal imaging to establish the cell surface heparan sulfate (HS) as a critical host factor exploited by SARS-CoV-2 to enhance spike’s fu...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Tang, Wei-Chun, Stancanelli, Eduardo, Jung, Eunkyung, Syed, Zulfeqhar, Pagadala, Vijayakanth, Saidi, Layla, Chen, Catherine Z., Gao, Peng, Xu, Miao, Pavlinov, Ivan, Li, Bing, Huang, Wenwei, Chen, Liqiang, Liu, Jian, Xie, Hang, Zheng, Wei, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081376/
https://www.ncbi.nlm.nih.gov/pubmed/37034606
http://dx.doi.org/10.21203/rs.3.rs-2693563/v1

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