Circadian disturbances and frailty risk in older adults: a prospective cohort study

Frailty is characterized by diminished resilience to stressor events. It associates with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates a ~24-h rhythm in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an i...

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Autores principales: Cai, Ruixue, Gao, Lei, Gao, Chenlu, Yu, Lei, Zheng, Xi, Bennett, David, Buchman, Aron, Hu, Kun, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081385/
https://www.ncbi.nlm.nih.gov/pubmed/37034594
http://dx.doi.org/10.21203/rs.3.rs-2648399/v1
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author Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David
Buchman, Aron
Hu, Kun
Li, Peng
author_facet Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David
Buchman, Aron
Hu, Kun
Li, Peng
author_sort Cai, Ruixue
collection PubMed
description Frailty is characterized by diminished resilience to stressor events. It associates with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates a ~24-h rhythm in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1,000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation, were associated with a higher risk of incident frailty, and faster worsening of the overall frailty symptoms over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.
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spelling pubmed-100813852023-04-08 Circadian disturbances and frailty risk in older adults: a prospective cohort study Cai, Ruixue Gao, Lei Gao, Chenlu Yu, Lei Zheng, Xi Bennett, David Buchman, Aron Hu, Kun Li, Peng Res Sq Article Frailty is characterized by diminished resilience to stressor events. It associates with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates a ~24-h rhythm in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1,000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation, were associated with a higher risk of incident frailty, and faster worsening of the overall frailty symptoms over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults. American Journal Experts 2023-03-27 /pmc/articles/PMC10081385/ /pubmed/37034594 http://dx.doi.org/10.21203/rs.3.rs-2648399/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David
Buchman, Aron
Hu, Kun
Li, Peng
Circadian disturbances and frailty risk in older adults: a prospective cohort study
title Circadian disturbances and frailty risk in older adults: a prospective cohort study
title_full Circadian disturbances and frailty risk in older adults: a prospective cohort study
title_fullStr Circadian disturbances and frailty risk in older adults: a prospective cohort study
title_full_unstemmed Circadian disturbances and frailty risk in older adults: a prospective cohort study
title_short Circadian disturbances and frailty risk in older adults: a prospective cohort study
title_sort circadian disturbances and frailty risk in older adults: a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081385/
https://www.ncbi.nlm.nih.gov/pubmed/37034594
http://dx.doi.org/10.21203/rs.3.rs-2648399/v1
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