A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics

Genome-wide association studies (GWAS) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While methods have been proposed to characterize pleiotropic components across groups of phenotypes, scaling these approaches to ultra large-scale biobanks h...

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Detalles Bibliográficos
Autores principales: Zhang, Zixuan, Jung, Junghyun, Kim, Artem, Suboc, Noah, Gazal, Steven, Mancuso, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081403/
https://www.ncbi.nlm.nih.gov/pubmed/37034739
http://dx.doi.org/10.1101/2023.03.27.23287801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081403/
https://www.ncbi.nlm.nih.gov/pubmed/37034739
http://dx.doi.org/10.1101/2023.03.27.23287801

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