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Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis

BACKGROUND: Genetic and experimental studies support a causal involvement of interleukin-6 (IL-6) signaling in atheroprogression. While trials targeting IL-6 signaling are underway, any benefits must be balanced against an impaired host immune response. Dissecting the mechanisms that mediate the eff...

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Detalles Bibliográficos
Autores principales:	Prapiadou, Savvina, Živković, Luka, Thorand, Barbara, George, Marc J., van der Laan, Sander W., Malik, Rainer, Herder, Christian, Koenig, Wolfgang, Ueland, Thor, Kleveland, Ola, Aukrust, Pal, Gullestad, Lars, Bernhagen, Jürgen, Pasterkamp, Gerard, Peters, Annette, Hingorani, Aroon D., Rosand, Jonathan, Dichgans, Martin, Anderson, Christopher D., Georgakis, Marios K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081435/ https://www.ncbi.nlm.nih.gov/pubmed/37034659 http://dx.doi.org/10.1101/2023.03.24.23287543

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