Non-viral TRAC-knocked-in CD19(KI)CAR-T and gp350(KI)CAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency

INTRODUCTION: The ubiquitous Epstein–Barr virus (EBV) is an oncogenic herpes virus associated with several human malignancies. EBV is an immune-evasive pathogen that promotes CD8(+) T cell exhaustion and dysregulates CD4(+) T cell functions. Burkitt lymphoma (BL) is frequently associated with EBV in...

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Detalles Bibliográficos
Autores principales: Braun, Tobias, Pruene, Alina, Darguzyte, Milita, vom Stein, Alexander F., Nguyen, Phuong-Hien, Wagner, Dimitrios L., Kath, Jonas, Roig-Merino, Alicia, Heuser, Michael, Riehm, Lucas L., Schneider, Andreas, Awerkiew, Sabine, Talbot, Steven R., Bleich, André, Figueiredo, Constanca, Bornhäuser, Martin, Stripecke, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081580/
https://www.ncbi.nlm.nih.gov/pubmed/37033919
http://dx.doi.org/10.3389/fimmu.2023.1086433

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