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Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India

India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a po...

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Autores principales: Rahi, Manju, Yadav, Chander Prakash, Ahmad, Sundus Shafat, Nitika, Das, Payal, Sharma, Shweta, Baharia, Rajendra Kumar, Bhattacharya, Debdutta, Deshmukh, Pradeep, Dhatrak, Amey, Dogra, Sandeep, Eapen, Alex, Goel, Pawan, Faizi, Nafis, Khan, Siraj A., Kochar, Sanjay Kumar, Kochar, Aditya, Kumar, Ashwani, Mundra, Anuj, Narang, Rahul, Narain, Kanwar, Pandey, Krishna, Pati, Sanghamitra, Raghav, Pankaja, Ranjha, Ritesh, Shah, Salman, Singh, Kuldeep, Singh, Piyoosh Kumar, Singh, Raj Kumar, Kuttiatt, Vijesh Shreedhar, Soni, Ravinder, Sreehari, Uragayala, Malhotra, Sumit, Sharma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081792/
https://www.ncbi.nlm.nih.gov/pubmed/37027349
http://dx.doi.org/10.1371/journal.pgph.0000946
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author Rahi, Manju
Yadav, Chander Prakash
Ahmad, Sundus Shafat
Nitika,
Das, Payal
Sharma, Shweta
Baharia, Rajendra Kumar
Bhattacharya, Debdutta
Deshmukh, Pradeep
Dhatrak, Amey
Dogra, Sandeep
Eapen, Alex
Goel, Pawan
Faizi, Nafis
Khan, Siraj A.
Kochar, Sanjay Kumar
Kochar, Aditya
Kumar, Ashwani
Mundra, Anuj
Narang, Rahul
Narain, Kanwar
Pandey, Krishna
Pati, Sanghamitra
Raghav, Pankaja
Ranjha, Ritesh
Shah, Salman
Singh, Kuldeep
Singh, Piyoosh Kumar
Singh, Raj Kumar
Kuttiatt, Vijesh Shreedhar
Soni, Ravinder
Sreehari, Uragayala
Malhotra, Sumit
Sharma, Amit
author_facet Rahi, Manju
Yadav, Chander Prakash
Ahmad, Sundus Shafat
Nitika,
Das, Payal
Sharma, Shweta
Baharia, Rajendra Kumar
Bhattacharya, Debdutta
Deshmukh, Pradeep
Dhatrak, Amey
Dogra, Sandeep
Eapen, Alex
Goel, Pawan
Faizi, Nafis
Khan, Siraj A.
Kochar, Sanjay Kumar
Kochar, Aditya
Kumar, Ashwani
Mundra, Anuj
Narang, Rahul
Narain, Kanwar
Pandey, Krishna
Pati, Sanghamitra
Raghav, Pankaja
Ranjha, Ritesh
Shah, Salman
Singh, Kuldeep
Singh, Piyoosh Kumar
Singh, Raj Kumar
Kuttiatt, Vijesh Shreedhar
Soni, Ravinder
Sreehari, Uragayala
Malhotra, Sumit
Sharma, Amit
author_sort Rahi, Manju
collection PubMed
description India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a potent tool to control and end the pandemic in addition to other control measures. India rolled out its vaccination programme on January 16, 2021, initially with two vaccines that were given emergency authorization–Covaxin (BBV152) and Covishield (ChAdOx1 nCoV- 19). Vaccination was initially started for the elderly (60+) and front-line workers and then gradually opened to different age groups. The second wave hit when vaccination was picking up pace in India. There were instances of vaccinated people (fully and partially) getting infected, and reinfections were also reported. We undertook a survey of staff (front line health care workers and supporting) of 15 medical colleges and research institutes across India to assess the vaccination coverage, incidence of breakthrough infections, and reinfections among them from June 2 to July 10, 2021. A total of 1876 staff participated, and 1484 forms were selected for analysis after removing duplicates and erroneous entries (n = 392). We found that among the respondents at the time of response, 17.6% were unvaccinated, 19.8% were partially vaccinated (received the first dose), and 62.5% were fully vaccinated (received both doses). Incidence of breakthrough infections was 8.7% among the 801 individuals (70/801) tested at least 14 days after the 2nd dose of vaccine. Eight participants reported reinfection in the overall infected group and reinfection incidence rate was 5.1%. Out of (N = 349) infected individuals 243 (69.6%) were unvaccinated and 106 (30.3%) were vaccinated. Our findings reveal the protective effect of vaccination and its role as an essential tool in the struggle against this pandemic.
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spelling pubmed-100817922023-04-08 Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India Rahi, Manju Yadav, Chander Prakash Ahmad, Sundus Shafat Nitika, Das, Payal Sharma, Shweta Baharia, Rajendra Kumar Bhattacharya, Debdutta Deshmukh, Pradeep Dhatrak, Amey Dogra, Sandeep Eapen, Alex Goel, Pawan Faizi, Nafis Khan, Siraj A. Kochar, Sanjay Kumar Kochar, Aditya Kumar, Ashwani Mundra, Anuj Narang, Rahul Narain, Kanwar Pandey, Krishna Pati, Sanghamitra Raghav, Pankaja Ranjha, Ritesh Shah, Salman Singh, Kuldeep Singh, Piyoosh Kumar Singh, Raj Kumar Kuttiatt, Vijesh Shreedhar Soni, Ravinder Sreehari, Uragayala Malhotra, Sumit Sharma, Amit PLOS Glob Public Health Research Article India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a potent tool to control and end the pandemic in addition to other control measures. India rolled out its vaccination programme on January 16, 2021, initially with two vaccines that were given emergency authorization–Covaxin (BBV152) and Covishield (ChAdOx1 nCoV- 19). Vaccination was initially started for the elderly (60+) and front-line workers and then gradually opened to different age groups. The second wave hit when vaccination was picking up pace in India. There were instances of vaccinated people (fully and partially) getting infected, and reinfections were also reported. We undertook a survey of staff (front line health care workers and supporting) of 15 medical colleges and research institutes across India to assess the vaccination coverage, incidence of breakthrough infections, and reinfections among them from June 2 to July 10, 2021. A total of 1876 staff participated, and 1484 forms were selected for analysis after removing duplicates and erroneous entries (n = 392). We found that among the respondents at the time of response, 17.6% were unvaccinated, 19.8% were partially vaccinated (received the first dose), and 62.5% were fully vaccinated (received both doses). Incidence of breakthrough infections was 8.7% among the 801 individuals (70/801) tested at least 14 days after the 2nd dose of vaccine. Eight participants reported reinfection in the overall infected group and reinfection incidence rate was 5.1%. Out of (N = 349) infected individuals 243 (69.6%) were unvaccinated and 106 (30.3%) were vaccinated. Our findings reveal the protective effect of vaccination and its role as an essential tool in the struggle against this pandemic. Public Library of Science 2023-04-07 /pmc/articles/PMC10081792/ /pubmed/37027349 http://dx.doi.org/10.1371/journal.pgph.0000946 Text en © 2023 Rahi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rahi, Manju
Yadav, Chander Prakash
Ahmad, Sundus Shafat
Nitika,
Das, Payal
Sharma, Shweta
Baharia, Rajendra Kumar
Bhattacharya, Debdutta
Deshmukh, Pradeep
Dhatrak, Amey
Dogra, Sandeep
Eapen, Alex
Goel, Pawan
Faizi, Nafis
Khan, Siraj A.
Kochar, Sanjay Kumar
Kochar, Aditya
Kumar, Ashwani
Mundra, Anuj
Narang, Rahul
Narain, Kanwar
Pandey, Krishna
Pati, Sanghamitra
Raghav, Pankaja
Ranjha, Ritesh
Shah, Salman
Singh, Kuldeep
Singh, Piyoosh Kumar
Singh, Raj Kumar
Kuttiatt, Vijesh Shreedhar
Soni, Ravinder
Sreehari, Uragayala
Malhotra, Sumit
Sharma, Amit
Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title_full Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title_fullStr Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title_full_unstemmed Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title_short Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India
title_sort vaccination coverage and breakthrough infections of covid-19 during the second wave among staff of selected medical institutions in india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081792/
https://www.ncbi.nlm.nih.gov/pubmed/37027349
http://dx.doi.org/10.1371/journal.pgph.0000946
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