Cargando…

A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development

The specialized cell types of the mucociliary epithelium (MCE) lining the respiratory tract enable continuous airway clearing, with its defects leading to chronic respiratory diseases. The molecular mechanisms driving cell fate acquisition and temporal specialization during mucociliary epithelial de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Julie, Møller, Andreas Fønss, Chae, Shinhyeok, Bussek, Alexandra, Park, Tae Joo, Kim, Youni, Lee, Hyun-Shik, Pers, Tune H., Kwon, Taejoon, Sedzinski, Jakub, Natarajan, Kedar Nath
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081853/ https://www.ncbi.nlm.nih.gov/pubmed/37027470 http://dx.doi.org/10.1126/sciadv.add5745

Ejemplares similares

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
por: Song, Daniel, et al.
Publicado: (2022)

Xenopus gpx3 Mediates Posterior Development by Regulating Cell Death during Embryogenesis
por: Lee, Hongchan, et al.
Publicado: (2020)

The Xenopus animal cap transcriptome: building a mucociliary epithelium
por: Angerilli, Alessandro, et al.
Publicado: (2018)

Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance
por: Sim, Hyo Jung, et al.
Publicado: (2022)

Varying mechanical forces drive sensory epithelium formation
por: Xia, Mingyu, et al.
Publicado: (2023)

Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids
por: Long, Qi, et al.
Publicado: (2023)

Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis
por: Murugan, Nirosha J., et al.
Publicado: (2022)

A succinate/SUCNR1-brush cell defense program in the tracheal epithelium
por: Perniss, Alexander, et al.
Publicado: (2023)

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation
por: Pikkupeura, Laura M., et al.
Publicado: (2023)

Predicting gene regulatory networks from cell atlases
por: Møller, Andreas Fønss, et al.
Publicado: (2020)

Topology of the redox network during induction of photosynthesis as revealed by time-resolved proteomics in tobacco
por: Zimmer, David, et al.
Publicado: (2021)

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
por: Mercau, Maria E., et al.
Publicado: (2023)

Cis-regulatory chromatin loops analysis identifies GRHL3 as a master regulator of surface epithelium commitment
por: Huang, Huaxing, et al.
Publicado: (2022)

Multimorbidity patterns with K-means nonhierarchical cluster analysis
por: Violán, Concepción, et al.
Publicado: (2018)

Hierarchical and nonhierarchical features of the mouse visual cortical network
por: D’Souza, Rinaldo D., et al.
Publicado: (2022)

Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
por: Fukuda, Shinichi, et al.
Publicado: (2021)

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways
por: Yu, Zhi, et al.
Publicado: (2022)

Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development
por: Lee, Hongchan, et al.
Publicado: (2021)

Acute effects of inhalable particles on the frog palate mucociliary epithelium.
por: Macchione, M, et al.
Publicado: (1999)

Chemical composition modulates the adverse effects of particles on the mucociliary epithelium
por: Carvalho-Oliveira, Regiani, et al.
Publicado: (2015)

Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia
por: Barsan, Valentin, et al.
Publicado: (2022)

De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variants
por: Lee, Minjong, et al.
Publicado: (2022)

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy
por: Han, Jeong Pil, et al.
Publicado: (2022)

Priority Effects and Nonhierarchical Competition Shape Species Composition in a Complex Grassland Community
por: Uricchio, Lawrence H., et al.
Publicado: (2019)

Structural basis for CEP192-mediated regulation of centrosomal AURKA
por: Park, Jin-Gyeong, et al.
Publicado: (2023)

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone
por: Lee, Ching-Han, et al.
Publicado: (2023)

Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs
por: Kim, Da-Seul, et al.
Publicado: (2021)

A ligand-independent Tie2-activating antibody reduces vascular leakage in models of Clarkson disease
por: Ablooglu, Ararat J., et al.
Publicado: (2023)

Quantitative and ultrasensitive in situ immunoassay technology for SARS-CoV-2 detection in saliva
por: Chen, Yuchao, et al.
Publicado: (2022)

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods
por: Katz, Daniel H., et al.
Publicado: (2022)

STAT1 maintains naïve CD8(+) T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
por: Kye, Yoon-Chul, et al.
Publicado: (2021)

Longitudinal dynamics of the tumor hypoxia response: From enzyme activity to biological phenotype
por: Lee, Sandy Che-Eun S., et al.
Publicado: (2023)

Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies
por: Son, Keun Hong, et al.
Publicado: (2023)

Hematopoietic stem cells temporally transition to thrombopoietin dependence in the fetal liver
por: Lee, Yeojin, et al.
Publicado: (2022)

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
por: Choi, Insup, et al.
Publicado: (2022)

Maintenance of genome sequence integrity in long- and short-lived rodent species
por: Zhang, Lei, et al.
Publicado: (2021)

Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin
por: Ha, Jeongmin, et al.
Publicado: (2022)

Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia
por: Ohtsuka, Daisuke, et al.
Publicado: (2022)

Identification of the niche and mobilization mechanism for tissue-protective multipotential bone marrow ILC progenitors
por: Liu, Qingyang, et al.
Publicado: (2022)

HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus
por: Chinnapaiyan, S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qkvrf5jj1ski85rg8lmbmd9b6c