Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease

Alzheimer’s disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological process...

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Autores principales: Xiong, Fengzhen, Li, Chenglong, Wang, Qingbo, Geng, Xin, Yuan, Zhengbo, Li, Zefu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081979/
https://www.ncbi.nlm.nih.gov/pubmed/36826468
http://dx.doi.org/10.1007/s12031-023-02107-0
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author Xiong, Fengzhen
Li, Chenglong
Wang, Qingbo
Geng, Xin
Yuan, Zhengbo
Li, Zefu
author_facet Xiong, Fengzhen
Li, Chenglong
Wang, Qingbo
Geng, Xin
Yuan, Zhengbo
Li, Zefu
author_sort Xiong, Fengzhen
collection PubMed
description Alzheimer’s disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer’s disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer’s disease patients were downloaded from the GEO database. Finally, we screened chromatin regulators related to Alzheimer's disease immunity, established prediction models, and screened related drugs and miRNAs. We screened 160 differentially expressed CRs, constructed an interaction network, obtained 10 hub genes, successfully constructed a prediction model based on immune-related 5 CRs, and obtained 520 related drugs and 3 related miRNA, which provided an idea for the treatment of Alzheimer's disease. Our study identified 5 chromatin regulators related to Alzheimer’s disease, which are expected to be new targets for Alzheimer’s disease immunotherapy.
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spelling pubmed-100819792023-04-09 Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease Xiong, Fengzhen Li, Chenglong Wang, Qingbo Geng, Xin Yuan, Zhengbo Li, Zefu J Mol Neurosci Article Alzheimer’s disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer’s disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer’s disease patients were downloaded from the GEO database. Finally, we screened chromatin regulators related to Alzheimer's disease immunity, established prediction models, and screened related drugs and miRNAs. We screened 160 differentially expressed CRs, constructed an interaction network, obtained 10 hub genes, successfully constructed a prediction model based on immune-related 5 CRs, and obtained 520 related drugs and 3 related miRNA, which provided an idea for the treatment of Alzheimer's disease. Our study identified 5 chromatin regulators related to Alzheimer’s disease, which are expected to be new targets for Alzheimer’s disease immunotherapy. Springer US 2023-02-24 2023 /pmc/articles/PMC10081979/ /pubmed/36826468 http://dx.doi.org/10.1007/s12031-023-02107-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xiong, Fengzhen
Li, Chenglong
Wang, Qingbo
Geng, Xin
Yuan, Zhengbo
Li, Zefu
Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title_full Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title_fullStr Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title_full_unstemmed Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title_short Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease
title_sort identification of chromatin regulatory factors related to immunity and treatment of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081979/
https://www.ncbi.nlm.nih.gov/pubmed/36826468
http://dx.doi.org/10.1007/s12031-023-02107-0
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