Cargando…
Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy
In myotonic dystrophy type 1 (DM1), deregulated alternative splicing of the muscle chloride channel Clcn1 causes myotonia, a delayed relaxation of muscles due to repetitive action potentials. The degree of weakness in adult DM1 is associated with increased frequency of oxidative muscle fibers. Howev...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082032/ https://www.ncbi.nlm.nih.gov/pubmed/37029100 http://dx.doi.org/10.1038/s41467-023-37619-1 |