The synthesis and properties of mitochondrial targeted iron chelators

Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels...

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Autores principales: Cilibrizzi, Agostino, Pourzand, Charareh, Abbate, Vincenzo, Reelfs, Olivier, Versari, Laura, Floresta, Giuseppe, Hider, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082125/
https://www.ncbi.nlm.nih.gov/pubmed/35366134
http://dx.doi.org/10.1007/s10534-022-00383-8
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author Cilibrizzi, Agostino
Pourzand, Charareh
Abbate, Vincenzo
Reelfs, Olivier
Versari, Laura
Floresta, Giuseppe
Hider, Robert
author_facet Cilibrizzi, Agostino
Pourzand, Charareh
Abbate, Vincenzo
Reelfs, Olivier
Versari, Laura
Floresta, Giuseppe
Hider, Robert
author_sort Cilibrizzi, Agostino
collection PubMed
description Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.
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spelling pubmed-100821252023-04-09 The synthesis and properties of mitochondrial targeted iron chelators Cilibrizzi, Agostino Pourzand, Charareh Abbate, Vincenzo Reelfs, Olivier Versari, Laura Floresta, Giuseppe Hider, Robert Biometals Article Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria. Springer Netherlands 2022-04-02 2023 /pmc/articles/PMC10082125/ /pubmed/35366134 http://dx.doi.org/10.1007/s10534-022-00383-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cilibrizzi, Agostino
Pourzand, Charareh
Abbate, Vincenzo
Reelfs, Olivier
Versari, Laura
Floresta, Giuseppe
Hider, Robert
The synthesis and properties of mitochondrial targeted iron chelators
title The synthesis and properties of mitochondrial targeted iron chelators
title_full The synthesis and properties of mitochondrial targeted iron chelators
title_fullStr The synthesis and properties of mitochondrial targeted iron chelators
title_full_unstemmed The synthesis and properties of mitochondrial targeted iron chelators
title_short The synthesis and properties of mitochondrial targeted iron chelators
title_sort synthesis and properties of mitochondrial targeted iron chelators
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082125/
https://www.ncbi.nlm.nih.gov/pubmed/35366134
http://dx.doi.org/10.1007/s10534-022-00383-8
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