Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

CLEC-2 is a target for a new class of antiplatelet agent. Clustering of CLEC-2 leads to phosphorylation of a cytosolic YxxL and binding of the tandem SH2 domains in Syk, crosslinking two receptors. We have raised 48 nanobodies to CLEC-2 and crosslinked the most potent of these to generate divalent a...

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Detalles Bibliográficos
Autores principales: Clark, Joanne C., Martin, Eleyna M., Morán, Luis A., Di, Ying, Wang, Xueqing, Zuidscherwoude, Malou, Brown, Helena C., Kavanagh, Deirdre M., Hummert, Johan, Eble, Johannes A., Nieswandt, Bernhard, Stegner, David, Pollitt, Alice Y., Herten, Dirk-Peter, Tomlinson, Michael G., García, Angel, Watson, Steve P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082178/
https://www.ncbi.nlm.nih.gov/pubmed/37029319
http://dx.doi.org/10.1038/s42003-023-04766-6

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