Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

Malaria parasites like Plasmodium falciparum multiply in red blood cells (RBC), which are cleared from the bloodstream by the spleen when their deformability is altered. Drug-induced stiffening of Plasmodium falciparum-infected RBC should therefore induce their elimination from the bloodstream. Here...

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Detalles Bibliográficos
Autores principales: Carucci, Mario, Duez, Julien, Tarning, Joel, García-Barbazán, Irene, Fricot-Monsinjon, Aurélie, Sissoko, Abdoulaye, Dumas, Lucie, Gamallo, Pablo, Beher, Babette, Amireault, Pascal, Dussiot, Michael, Dao, Ming, Hull, Mitchell V., McNamara, Case W., Roussel, Camille, Ndour, Papa Alioune, Sanz, Laura Maria, Gamo, Francisco Javier, Buffet, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082216/
https://www.ncbi.nlm.nih.gov/pubmed/37029122
http://dx.doi.org/10.1038/s41467-023-37359-2

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