Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion

A 32-year-old patient with COVID-19 pneumonia and pericardial effusion mistakenly took 15 mg of colchicine over 10 hours. He developed diarrhea that resolved two days after colchicine was stopped. Remarkably, this single overdose of colchicine, without any additional therapy, resulted in the complet...

Descripción completa

Detalles Bibliográficos
Autores principales: Mondeshki, Tsanko, Bilyukov, Radoslav, Mitev, Vanyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082222/
https://www.ncbi.nlm.nih.gov/pubmed/37038575
http://dx.doi.org/10.7759/cureus.35909
_version_ 1785021274545717248
author Mondeshki, Tsanko
Bilyukov, Radoslav
Mitev, Vanyo
author_facet Mondeshki, Tsanko
Bilyukov, Radoslav
Mitev, Vanyo
author_sort Mondeshki, Tsanko
collection PubMed
description A 32-year-old patient with COVID-19 pneumonia and pericardial effusion mistakenly took 15 mg of colchicine over 10 hours. He developed diarrhea that resolved two days after colchicine was stopped. Remarkably, this single overdose of colchicine, without any additional therapy, resulted in the complete recovery of bilateral pneumonia and pericardial effusion, and the patient was discharged on the hospital day 9th. This case demonstrates the possibility that high colchicine doses may have a major role and a dramatic effect in the treatment of COVID-19 patients.
format Online
Article
Text
id pubmed-10082222
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-100822222023-04-09 Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion Mondeshki, Tsanko Bilyukov, Radoslav Mitev, Vanyo Cureus Infectious Disease A 32-year-old patient with COVID-19 pneumonia and pericardial effusion mistakenly took 15 mg of colchicine over 10 hours. He developed diarrhea that resolved two days after colchicine was stopped. Remarkably, this single overdose of colchicine, without any additional therapy, resulted in the complete recovery of bilateral pneumonia and pericardial effusion, and the patient was discharged on the hospital day 9th. This case demonstrates the possibility that high colchicine doses may have a major role and a dramatic effect in the treatment of COVID-19 patients. Cureus 2023-03-08 /pmc/articles/PMC10082222/ /pubmed/37038575 http://dx.doi.org/10.7759/cureus.35909 Text en Copyright © 2023, Mondeshki et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Mondeshki, Tsanko
Bilyukov, Radoslav
Mitev, Vanyo
Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title_full Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title_fullStr Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title_full_unstemmed Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title_short Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
title_sort effect of an accidental colchicine overdose in a covid-19 inpatient with bilateral pneumonia and pericardial effusion
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082222/
https://www.ncbi.nlm.nih.gov/pubmed/37038575
http://dx.doi.org/10.7759/cureus.35909
work_keys_str_mv AT mondeshkitsanko effectofanaccidentalcolchicineoverdoseinacovid19inpatientwithbilateralpneumoniaandpericardialeffusion
AT bilyukovradoslav effectofanaccidentalcolchicineoverdoseinacovid19inpatientwithbilateralpneumoniaandpericardialeffusion
AT mitevvanyo effectofanaccidentalcolchicineoverdoseinacovid19inpatientwithbilateralpneumoniaandpericardialeffusion

Ejemplares similares