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Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center
We aimed to determine the association between disease activity during pregnancy and pregnancy outcomes of women with polymyositis and dermatomyositis (PM/DM). Patients with PM/DM who were managed from pregnancy to delivery at Kagawa University Hospital from March 2006 to May 2021 were enrolled. Clin...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082272/ https://www.ncbi.nlm.nih.gov/pubmed/37026900 http://dx.doi.org/10.1097/MD.0000000000033462 |
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author | Mino, Rina Shimada, Hiromi Wakiya, Risa Nakashima, Shusaku Miyagi, Taichi Sugihara, Koichi Ushio, Yusuke Mizusaki, Mao Chujo, Kanako Kameda, Tomohiro Kanenishi, Kenji Kadowaki, Norimitsu Dobashi, Hiroaki |
author_facet | Mino, Rina Shimada, Hiromi Wakiya, Risa Nakashima, Shusaku Miyagi, Taichi Sugihara, Koichi Ushio, Yusuke Mizusaki, Mao Chujo, Kanako Kameda, Tomohiro Kanenishi, Kenji Kadowaki, Norimitsu Dobashi, Hiroaki |
author_sort | Mino, Rina |
collection | PubMed |
description | We aimed to determine the association between disease activity during pregnancy and pregnancy outcomes of women with polymyositis and dermatomyositis (PM/DM). Patients with PM/DM who were managed from pregnancy to delivery at Kagawa University Hospital from March 2006 to May 2021 were enrolled. Clinical data were retrospectively analyzed to evaluate the association between disease activity during pregnancy and pregnancy outcomes. Eight pregnancies in 5 women with PM/DM were analyzed. The mean age at conception was 28.3 ± 3.8 years, and mean disease duration was 6.3 ± 3.2 years. Four patients required an increased glucocorticoid dosage because of worsening disease activity (sustained elevation of creatine phosphokinase [CPK] concentration). Two patients who continuously received immunosuppressive drugs from conception to delivery showed no increase in disease activity and did not need increased glucocorticoid dosages. The pregnancy outcomes were 1 spontaneous abortion and 7 live births. The mean gestation length was 35.3 ± 5.2 weeks, and mean birthweight was 2297.7 ± 1041.4 g. Five adverse pregnancy outcomes (APOs) occurred (2 preterm births and 4 low birthweights); most of these cases had sustained elevation of CPK concentration and increased glucocorticoid dosages. No APOs occurred in the 2 patients who received continuous immunosuppressive medication. Continued use of pregnancy-compatible medications and control of disease activity with lower glucocorticoid dosages in pregnancies with PM/DM may be important to achieve good pregnancy outcomes. |
format | Online Article Text |
id | pubmed-10082272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100822722023-04-09 Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center Mino, Rina Shimada, Hiromi Wakiya, Risa Nakashima, Shusaku Miyagi, Taichi Sugihara, Koichi Ushio, Yusuke Mizusaki, Mao Chujo, Kanako Kameda, Tomohiro Kanenishi, Kenji Kadowaki, Norimitsu Dobashi, Hiroaki Medicine (Baltimore) 6900 We aimed to determine the association between disease activity during pregnancy and pregnancy outcomes of women with polymyositis and dermatomyositis (PM/DM). Patients with PM/DM who were managed from pregnancy to delivery at Kagawa University Hospital from March 2006 to May 2021 were enrolled. Clinical data were retrospectively analyzed to evaluate the association between disease activity during pregnancy and pregnancy outcomes. Eight pregnancies in 5 women with PM/DM were analyzed. The mean age at conception was 28.3 ± 3.8 years, and mean disease duration was 6.3 ± 3.2 years. Four patients required an increased glucocorticoid dosage because of worsening disease activity (sustained elevation of creatine phosphokinase [CPK] concentration). Two patients who continuously received immunosuppressive drugs from conception to delivery showed no increase in disease activity and did not need increased glucocorticoid dosages. The pregnancy outcomes were 1 spontaneous abortion and 7 live births. The mean gestation length was 35.3 ± 5.2 weeks, and mean birthweight was 2297.7 ± 1041.4 g. Five adverse pregnancy outcomes (APOs) occurred (2 preterm births and 4 low birthweights); most of these cases had sustained elevation of CPK concentration and increased glucocorticoid dosages. No APOs occurred in the 2 patients who received continuous immunosuppressive medication. Continued use of pregnancy-compatible medications and control of disease activity with lower glucocorticoid dosages in pregnancies with PM/DM may be important to achieve good pregnancy outcomes. Lippincott Williams & Wilkins 2022-04-07 /pmc/articles/PMC10082272/ /pubmed/37026900 http://dx.doi.org/10.1097/MD.0000000000033462 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 6900 Mino, Rina Shimada, Hiromi Wakiya, Risa Nakashima, Shusaku Miyagi, Taichi Sugihara, Koichi Ushio, Yusuke Mizusaki, Mao Chujo, Kanako Kameda, Tomohiro Kanenishi, Kenji Kadowaki, Norimitsu Dobashi, Hiroaki Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title | Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title_full | Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title_fullStr | Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title_full_unstemmed | Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title_short | Pregnancy course and outcomes of patients with polymyositis and dermatomyositis (PM/DM) managed in a single center |
title_sort | pregnancy course and outcomes of patients with polymyositis and dermatomyositis (pm/dm) managed in a single center |
topic | 6900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082272/ https://www.ncbi.nlm.nih.gov/pubmed/37026900 http://dx.doi.org/10.1097/MD.0000000000033462 |
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