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PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy

Chronic endoplasmic reticulum (ER) stress is the underlying cause of many degenerative diseases, including autosomal dominant retinitis pigmentosa (adRP). In adRP, mutant rhodopsins accumulate and cause ER stress. This destabilizes wild-type rhodopsin and triggers photoreceptor cell degeneration. To...

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Detalles Bibliográficos
Autores principales:	Zhao, Ning, Li, Ning, Wang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082367/ https://www.ncbi.nlm.nih.gov/pubmed/37022709 http://dx.doi.org/10.1083/jcb.202208147

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