Cargando…

GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides

To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d(Blood))...

Descripción completa

Detalles Bibliográficos
Autores principales: Salas-Ramirez, Maikol, Lassmann, Michael, Eberlein, Uta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082371/
https://www.ncbi.nlm.nih.gov/pubmed/35623943
http://dx.doi.org/10.1016/j.zemedi.2022.03.005
_version_ 1785021304144920576
author Salas-Ramirez, Maikol
Lassmann, Michael
Eberlein, Uta
author_facet Salas-Ramirez, Maikol
Lassmann, Michael
Eberlein, Uta
author_sort Salas-Ramirez, Maikol
collection PubMed
description To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d(Blood)) must be determined. d(Blood) is specific for each radionuclide, and it depends on the irradiation geometry. Therefore, the aim of this study is to use the Monte Carlo radiation transport code GATE/Geant4 to calculate the mean absorbed dose rates for ex vivo irradiation of blood with several radionuclides used in Nuclear Medicine. METHODS: The Monte Carlo simulation reproduces the irradiation geometry of a blood sample of 7 ml mixed with 1 ml of a water equivalent radioactive solution in an 8 ml vial. The simulation was performed for ten different radionuclides: (18)F, (68)Ga, (90)Y, (99m)Tc, (123)I, (124)I, (131)I, (177)Lu, (223)Ra, and (225)Ac. Two sets of simulations for each radionuclide were performed with 1x10(9) histories. The first set was simulated with a mass density of 1.0525 g/cm(3) of the blood plus water mixture. The second set of simulations was performed with a mass density of 1 g/cm(3) for comparison with previous studies. RESULTS: The values of d(Blood) for ten radionuclides were calculated. The values range from 10.23 mGy∙ml∙MBq(−1) for (99m)Tc to 15632.02 mGy∙ml∙MBq(−1) for (225)Ac. The maximum relative change compared to previous studies was 13.0% for (124)I. CONCLUSION: This study provides a comprehensive set of absorbed dose coefficients for 1 ml for 1 h internal ex vivo irradiation of peripheral blood in a special vial geometry and radionuclides typically used in Nuclear Medicine. Furthermore, the method proposed by this work can be easily adapted to a variety of internal irradiation conditions and serve as a reference for future studies.
format Online
Article
Text
id pubmed-10082371
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-100823712023-04-09 GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides Salas-Ramirez, Maikol Lassmann, Michael Eberlein, Uta Z Med Phys Original Paper To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d(Blood)) must be determined. d(Blood) is specific for each radionuclide, and it depends on the irradiation geometry. Therefore, the aim of this study is to use the Monte Carlo radiation transport code GATE/Geant4 to calculate the mean absorbed dose rates for ex vivo irradiation of blood with several radionuclides used in Nuclear Medicine. METHODS: The Monte Carlo simulation reproduces the irradiation geometry of a blood sample of 7 ml mixed with 1 ml of a water equivalent radioactive solution in an 8 ml vial. The simulation was performed for ten different radionuclides: (18)F, (68)Ga, (90)Y, (99m)Tc, (123)I, (124)I, (131)I, (177)Lu, (223)Ra, and (225)Ac. Two sets of simulations for each radionuclide were performed with 1x10(9) histories. The first set was simulated with a mass density of 1.0525 g/cm(3) of the blood plus water mixture. The second set of simulations was performed with a mass density of 1 g/cm(3) for comparison with previous studies. RESULTS: The values of d(Blood) for ten radionuclides were calculated. The values range from 10.23 mGy∙ml∙MBq(−1) for (99m)Tc to 15632.02 mGy∙ml∙MBq(−1) for (225)Ac. The maximum relative change compared to previous studies was 13.0% for (124)I. CONCLUSION: This study provides a comprehensive set of absorbed dose coefficients for 1 ml for 1 h internal ex vivo irradiation of peripheral blood in a special vial geometry and radionuclides typically used in Nuclear Medicine. Furthermore, the method proposed by this work can be easily adapted to a variety of internal irradiation conditions and serve as a reference for future studies. Elsevier 2022-05-24 /pmc/articles/PMC10082371/ /pubmed/35623943 http://dx.doi.org/10.1016/j.zemedi.2022.03.005 Text en © 2022 Published by Elsevier GmbH on behalf of DGMP, ÖGMP and SSRMP. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Paper
Salas-Ramirez, Maikol
Lassmann, Michael
Eberlein, Uta
GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title_full GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title_fullStr GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title_full_unstemmed GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title_short GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
title_sort gate/geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082371/
https://www.ncbi.nlm.nih.gov/pubmed/35623943
http://dx.doi.org/10.1016/j.zemedi.2022.03.005
work_keys_str_mv AT salasramirezmaikol gategeant4baseddosimetryforexvivoinsolutionirradiationofbloodwithradionuclides
AT lassmannmichael gategeant4baseddosimetryforexvivoinsolutionirradiationofbloodwithradionuclides
AT eberleinuta gategeant4baseddosimetryforexvivoinsolutionirradiationofbloodwithradionuclides