The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

BACKGROUND: Fragile X syndrome (FXS), the most common inherited intellectual disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein (FMRP). FMRP is an RNA-binding protein that negatively regulates the expression of many postsynaptic as well as presynaptic protei...

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Detalles Bibliográficos
Autores principales: Martín, Ricardo, Suárez-Pinilla, Alberto Samuel, García-Font, Nuria, Laguna-Luque, M. Luisa, López-Ramos, Juan C., Oset-Gasque, María Jesús, Gruart, Agnes, Delgado-García, José M., Torres, Magdalena, Sánchez-Prieto, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082511/
https://www.ncbi.nlm.nih.gov/pubmed/37029391
http://dx.doi.org/10.1186/s13229-023-00547-4

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