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Regulation of LncRNAs and microRNAs in neuronal development and disease

Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins but play important roles in regulating cellular processes. Multiple studies over the past decade have demonstrated the role of microRNAs (miRNAs) in cancer, in which some miRNAs can act as biomarkers or provide therapy target. Accumulatin...

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Autores principales: Xuan, Cheng, Yang, Enyu, Zhao, Shuo, Xu, Juan, Li, Peihang, Zhang, Yaping, Jiang, Zhenggang, Ding, Xianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082570/
https://www.ncbi.nlm.nih.gov/pubmed/37038472
http://dx.doi.org/10.7717/peerj.15197
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author Xuan, Cheng
Yang, Enyu
Zhao, Shuo
Xu, Juan
Li, Peihang
Zhang, Yaping
Jiang, Zhenggang
Ding, Xianfeng
author_facet Xuan, Cheng
Yang, Enyu
Zhao, Shuo
Xu, Juan
Li, Peihang
Zhang, Yaping
Jiang, Zhenggang
Ding, Xianfeng
author_sort Xuan, Cheng
collection PubMed
description Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins but play important roles in regulating cellular processes. Multiple studies over the past decade have demonstrated the role of microRNAs (miRNAs) in cancer, in which some miRNAs can act as biomarkers or provide therapy target. Accumulating evidence also points to the importance of long non-coding RNAs (lncRNAs) in regulating miRNA-mRNA networks. An increasing number of ncRNAs have been shown to be involved in the regulation of cellular processes, and dysregulation of ncRNAs often heralds disease. As the population ages, the incidence of neurodegenerative diseases is increasing, placing enormous pressure on global health systems. Given the excellent performance of ncRNAs in early cancer screening and treatment, here we attempted to aggregate and analyze the regulatory functions of ncRNAs in neuronal development and disease. In this review, we summarize current knowledge on ncRNA taxonomy, biogenesis, and function, and discuss current research progress on ncRNAs in relation to neuronal development, differentiation, and neurodegenerative diseases.
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spelling pubmed-100825702023-04-09 Regulation of LncRNAs and microRNAs in neuronal development and disease Xuan, Cheng Yang, Enyu Zhao, Shuo Xu, Juan Li, Peihang Zhang, Yaping Jiang, Zhenggang Ding, Xianfeng PeerJ Biochemistry Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins but play important roles in regulating cellular processes. Multiple studies over the past decade have demonstrated the role of microRNAs (miRNAs) in cancer, in which some miRNAs can act as biomarkers or provide therapy target. Accumulating evidence also points to the importance of long non-coding RNAs (lncRNAs) in regulating miRNA-mRNA networks. An increasing number of ncRNAs have been shown to be involved in the regulation of cellular processes, and dysregulation of ncRNAs often heralds disease. As the population ages, the incidence of neurodegenerative diseases is increasing, placing enormous pressure on global health systems. Given the excellent performance of ncRNAs in early cancer screening and treatment, here we attempted to aggregate and analyze the regulatory functions of ncRNAs in neuronal development and disease. In this review, we summarize current knowledge on ncRNA taxonomy, biogenesis, and function, and discuss current research progress on ncRNAs in relation to neuronal development, differentiation, and neurodegenerative diseases. PeerJ Inc. 2023-04-05 /pmc/articles/PMC10082570/ /pubmed/37038472 http://dx.doi.org/10.7717/peerj.15197 Text en ©2023 Xuan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biochemistry
Xuan, Cheng
Yang, Enyu
Zhao, Shuo
Xu, Juan
Li, Peihang
Zhang, Yaping
Jiang, Zhenggang
Ding, Xianfeng
Regulation of LncRNAs and microRNAs in neuronal development and disease
title Regulation of LncRNAs and microRNAs in neuronal development and disease
title_full Regulation of LncRNAs and microRNAs in neuronal development and disease
title_fullStr Regulation of LncRNAs and microRNAs in neuronal development and disease
title_full_unstemmed Regulation of LncRNAs and microRNAs in neuronal development and disease
title_short Regulation of LncRNAs and microRNAs in neuronal development and disease
title_sort regulation of lncrnas and micrornas in neuronal development and disease
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082570/
https://www.ncbi.nlm.nih.gov/pubmed/37038472
http://dx.doi.org/10.7717/peerj.15197
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