The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

The MUC2 mucin polymer is the main building unit of the intestinal mucus layers separating intestinal microbiota from the host epithelium. The MUC2 mucin is a large glycoprotein with a C-terminal domain similar to the MUC5AC and MUC5B mucins and the von Willebrand factor (VWF). A structural model of...

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Detalles Bibliográficos
Autores principales: Gallego, Pablo, Garcia-Bonete, Maria-Jose, Trillo-Muyo, Sergio, Recktenwald, Christian V., Johansson, Malin E. V., Hansson, Gunnar C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082768/
https://www.ncbi.nlm.nih.gov/pubmed/37031240
http://dx.doi.org/10.1038/s41467-023-37666-8

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