Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ whic...

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Detalles Bibliográficos
Autores principales: Li, Rui, Shao, Jingchen, Jin, Young-June, Kawase, Haruya, Ong, Yu Ting, Troidl, Kerstin, Quan, Qi, Wang, Lei, Bonnavion, Remy, Wietelmann, Astrid, Helmbacher, Francoise, Potente, Michael, Graumann, Johannes, Wettschureck, Nina, Offermanns, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082778/
https://www.ncbi.nlm.nih.gov/pubmed/37031213
http://dx.doi.org/10.1038/s41467-023-37671-x

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