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The IgG4 hinge with CD28 transmembrane domain improves V(H)H-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. Here, we develop CAR T cells targeting glypican-1 (GPC1), an oncofetal antigen expressed in pancreatic cancer. We report the generation of dromedary camel V(H)H nano...

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Detalles Bibliográficos
Autores principales:	Li, Nan, Quan, Alex, Li, Dan, Pan, Jiajia, Ren, Hua, Hoeltzel, Gerard, de Val, Natalia, Ashworth, Dana, Ni, Weiming, Zhou, Jing, Mackay, Sean, Hewitt, Stephen M., Cachau, Raul, Ho, Mitchell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082787/ https://www.ncbi.nlm.nih.gov/pubmed/37031249 http://dx.doi.org/10.1038/s41467-023-37616-4

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