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The evolution and international spread of extensively drug resistant Shigella sonnei
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082799/ https://www.ncbi.nlm.nih.gov/pubmed/37031199 http://dx.doi.org/10.1038/s41467-023-37672-w |
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| author | Mason, Lewis C. E. Greig, David R. Cowley, Lauren A. Partridge, Sally R. Martinez, Elena Blackwell, Grace A. Chong, Charlotte E. De Silva, P. Malaka Bengtsson, Rebecca J. Draper, Jenny L. Ginn, Andrew N. Sandaradura, Indy Sim, Eby M. Iredell, Jonathan R. Sintchenko, Vitali Ingle, Danielle J. Howden, Benjamin P. Lefèvre, Sophie Njamkepo, Elisabeth Weill, François-Xavier Ceyssens, Pieter-Jan Jenkins, Claire Baker, Kate S. |
| author_facet | Mason, Lewis C. E. Greig, David R. Cowley, Lauren A. Partridge, Sally R. Martinez, Elena Blackwell, Grace A. Chong, Charlotte E. De Silva, P. Malaka Bengtsson, Rebecca J. Draper, Jenny L. Ginn, Andrew N. Sandaradura, Indy Sim, Eby M. Iredell, Jonathan R. Sintchenko, Vitali Ingle, Danielle J. Howden, Benjamin P. Lefèvre, Sophie Njamkepo, Elisabeth Weill, François-Xavier Ceyssens, Pieter-Jan Jenkins, Claire Baker, Kate S. |
| author_sort | Mason, Lewis C. E. |
| collection | PubMed |
| description | Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data. |
| format | Online Article Text |
| id | pubmed-10082799 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100827992023-04-10 The evolution and international spread of extensively drug resistant Shigella sonnei Mason, Lewis C. E. Greig, David R. Cowley, Lauren A. Partridge, Sally R. Martinez, Elena Blackwell, Grace A. Chong, Charlotte E. De Silva, P. Malaka Bengtsson, Rebecca J. Draper, Jenny L. Ginn, Andrew N. Sandaradura, Indy Sim, Eby M. Iredell, Jonathan R. Sintchenko, Vitali Ingle, Danielle J. Howden, Benjamin P. Lefèvre, Sophie Njamkepo, Elisabeth Weill, François-Xavier Ceyssens, Pieter-Jan Jenkins, Claire Baker, Kate S. Nat Commun Article Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data. Nature Publishing Group UK 2023-04-08 /pmc/articles/PMC10082799/ /pubmed/37031199 http://dx.doi.org/10.1038/s41467-023-37672-w Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Mason, Lewis C. E. Greig, David R. Cowley, Lauren A. Partridge, Sally R. Martinez, Elena Blackwell, Grace A. Chong, Charlotte E. De Silva, P. Malaka Bengtsson, Rebecca J. Draper, Jenny L. Ginn, Andrew N. Sandaradura, Indy Sim, Eby M. Iredell, Jonathan R. Sintchenko, Vitali Ingle, Danielle J. Howden, Benjamin P. Lefèvre, Sophie Njamkepo, Elisabeth Weill, François-Xavier Ceyssens, Pieter-Jan Jenkins, Claire Baker, Kate S. The evolution and international spread of extensively drug resistant Shigella sonnei |
| title | The evolution and international spread of extensively drug resistant Shigella sonnei |
| title_full | The evolution and international spread of extensively drug resistant Shigella sonnei |
| title_fullStr | The evolution and international spread of extensively drug resistant Shigella sonnei |
| title_full_unstemmed | The evolution and international spread of extensively drug resistant Shigella sonnei |
| title_short | The evolution and international spread of extensively drug resistant Shigella sonnei |
| title_sort | evolution and international spread of extensively drug resistant shigella sonnei |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082799/ https://www.ncbi.nlm.nih.gov/pubmed/37031199 http://dx.doi.org/10.1038/s41467-023-37672-w |
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